TY - JOUR
T1 - High-gamma activity in an attention network predicts individual differences in elderly adults' behavioral performance
AU - Akimoto, Yoritaka
AU - Nozawa, Takayuki
AU - Kanno, Akitake
AU - Ihara, Mizuki
AU - Goto, Takakuni
AU - Ogawa, Takeshi
AU - Kambara, Toshimune
AU - Sugiura, Motoaki
AU - Okumura, Eiichi
AU - Kawashima, Ryuta
N1 - Funding Information:
This work was supported by a Grant-In-Aid for young scientists (B) ( 23700305 ) from the Japan Society for the Promotion of Science . We would like to thank Yuki Yamada for her support with the MEG experiment and to Editage for providing editorial assistance and publication support.
PY - 2014/10/15
Y1 - 2014/10/15
N2 - The current study used a magnetoencephalogram to investigate the relationship between high-gamma (52-100. Hz) activity within an attention network and individual differences in behavioral performance among healthy elderly adults. We analyzed brain activity in 41 elderly subjects performing a 3-stimulus visual oddball task. In addition to the average amplitude of event-related fields in the left intraparietal sulcus (IPS), high-gamma power in the left middle frontal gyrus (MFG), the strength of high-gamma imaginary coherence between the right MFG and the left MFG, and those between the right MFG and the left thalamus predicted individual differences in reaction time. In addition, high-gamma power in the left MFG was correlated with task accuracy, whereas high-gamma power in the left thalamus and left IPS was correlated with individual processing speed. The direction of correlations indicated that higher high-gamma power or coherence in an attention network was associated with better task performance and, presumably, higher cognitive function. Thus, high-gamma activity in different regions of this attention network differentially contributed to attentional processing, and such activity could be a fundamental process associated with individual differences in cognitive aging.
AB - The current study used a magnetoencephalogram to investigate the relationship between high-gamma (52-100. Hz) activity within an attention network and individual differences in behavioral performance among healthy elderly adults. We analyzed brain activity in 41 elderly subjects performing a 3-stimulus visual oddball task. In addition to the average amplitude of event-related fields in the left intraparietal sulcus (IPS), high-gamma power in the left middle frontal gyrus (MFG), the strength of high-gamma imaginary coherence between the right MFG and the left MFG, and those between the right MFG and the left thalamus predicted individual differences in reaction time. In addition, high-gamma power in the left MFG was correlated with task accuracy, whereas high-gamma power in the left thalamus and left IPS was correlated with individual processing speed. The direction of correlations indicated that higher high-gamma power or coherence in an attention network was associated with better task performance and, presumably, higher cognitive function. Thus, high-gamma activity in different regions of this attention network differentially contributed to attentional processing, and such activity could be a fundamental process associated with individual differences in cognitive aging.
KW - Aging
KW - Attention
KW - High-gamma activities
KW - Individual differences
KW - Reaction time
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U2 - 10.1016/j.neuroimage.2014.06.037
DO - 10.1016/j.neuroimage.2014.06.037
M3 - Article
C2 - 24960420
AN - SCOPUS:84904070986
SN - 1053-8119
VL - 100
SP - 290
EP - 300
JO - NeuroImage
JF - NeuroImage
ER -