High Level Expression of Human α-Fetoprotein in Transgenic Mice

T. Yamashita, N. Kasai, I. Miyoshi, N. Sasaki, K. Maki, M. Sakai, S. Nishi, S. Namioka

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Transgenic mice were produced by the microinjection of the cDNA of human alphafetoprotein (AFP) under control of the enhancer/promoter of the human β-actin gene. Among the 4 mouse lines where the transgene were stable transmitted to the progeny, 3 produced human AFP. The expression was not developmental stage-specific nor tissue-specific as predicted from the properties of enhancer/promoter. The serum human AFP levels of adult mice were 30∼600-fold higher than those of mouse AFP. These mice could be useful for the studies of possible biological functions of AFP during development as well as in malignancies.

Original languageEnglish
Pages (from-to)715-720
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number2
Publication statusPublished - 1993 Mar 15


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