High-performance liquid chromatography with photodiode array detection for determination of nobiletin content in the brain and serum of mice administrated the natural compound

Daisuke Saigusa; Masatoshi Shibuya; Daisuke Jinno; Hiroyuki Yamakoshi; Yoshiharu Iwabuchi; Akihito Yokosuka; Yoshihiro Mimaki; Akira Naganuma; Yasushi Ohizumi; Yoshihisa Tomioka; Tohru Yamakuni

doi:10.1007/s00216-011-5031-2

High-performance liquid chromatography with photodiode array detection for determination of nobiletin content in the brain and serum of mice administrated the natural compound

Daisuke Saigusa, Masatoshi Shibuya, Daisuke Jinno, Hiroyuki Yamakoshi, Yoshiharu Iwabuchi, Akihito Yokosuka, Yoshihiro Mimaki, Akira Naganuma, Yasushi Ohizumi, Yoshihisa Tomioka, Tohru Yamakuni

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

We recently demonstrated that nobiletin, a citrus flavonoid, exhibits anti-dementia action in animals. However, no determination methods for the content of nobiletin with beneficial action in the brain of nobiletin- administered animals have been developed, nor has its pharmacokinetics been revealed completely. Here, we established the high-performance liquid chromatography/photodiode array detection method for nobiletin determination using Bond Elut C18 SPE cartridges for extraction, where the calibration curve was linear over 0.025-10 ng, with coefficient of variation of less than 6.76%. This method enabled us to determine pharmacokinetic parameters of nobiletin given intraperitoneally or per os in the brain of mice.

Original language	English
Pages (from-to)	3635-3641
Number of pages	7
Journal	Analytical and Bioanalytical Chemistry
Volume	400
Issue number	10
DOIs	https://doi.org/10.1007/s00216-011-5031-2
Publication status	Published - 2011 Jul

Keywords

Brain
Dementia
High-performance liquid chromatography
Nobiletin
Pharmacokinetics
Photodiode array

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10.1007/s00216-011-5031-2

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Saigusa, D., Shibuya, M., Jinno, D., Yamakoshi, H., Iwabuchi, Y., Yokosuka, A., Mimaki, Y., Naganuma, A., Ohizumi, Y., Tomioka, Y., & Yamakuni, T. (2011). High-performance liquid chromatography with photodiode array detection for determination of nobiletin content in the brain and serum of mice administrated the natural compound. Analytical and Bioanalytical Chemistry, 400(10), 3635-3641. https://doi.org/10.1007/s00216-011-5031-2

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title = "High-performance liquid chromatography with photodiode array detection for determination of nobiletin content in the brain and serum of mice administrated the natural compound",

abstract = "We recently demonstrated that nobiletin, a citrus flavonoid, exhibits anti-dementia action in animals. However, no determination methods for the content of nobiletin with beneficial action in the brain of nobiletin- administered animals have been developed, nor has its pharmacokinetics been revealed completely. Here, we established the high-performance liquid chromatography/photodiode array detection method for nobiletin determination using Bond Elut C18 SPE cartridges for extraction, where the calibration curve was linear over 0.025-10 ng, with coefficient of variation of less than 6.76%. This method enabled us to determine pharmacokinetic parameters of nobiletin given intraperitoneally or per os in the brain of mice.",

keywords = "Brain, Dementia, High-performance liquid chromatography, Nobiletin, Pharmacokinetics, Photodiode array",

author = "Daisuke Saigusa and Masatoshi Shibuya and Daisuke Jinno and Hiroyuki Yamakoshi and Yoshiharu Iwabuchi and Akihito Yokosuka and Yoshihiro Mimaki and Akira Naganuma and Yasushi Ohizumi and Yoshihisa Tomioka and Tohru Yamakuni",

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Saigusa, D, Shibuya, M, Jinno, D, Yamakoshi, H , Iwabuchi, Y, Yokosuka, A, Mimaki, Y, Naganuma, A, Ohizumi, Y, Tomioka, Y & Yamakuni, T 2011, 'High-performance liquid chromatography with photodiode array detection for determination of nobiletin content in the brain and serum of mice administrated the natural compound', Analytical and Bioanalytical Chemistry, vol. 400, no. 10, pp. 3635-3641. https://doi.org/10.1007/s00216-011-5031-2

High-performance liquid chromatography with photodiode array detection for determination of nobiletin content in the brain and serum of mice administrated the natural compound. / Saigusa, Daisuke; Shibuya, Masatoshi; Jinno, Daisuke et al.
In: Analytical and Bioanalytical Chemistry, Vol. 400, No. 10, 07.2011, p. 3635-3641.

Research output: Contribution to journal › Article › peer-review

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AU - Saigusa, Daisuke

AU - Shibuya, Masatoshi

AU - Jinno, Daisuke

AU - Yamakoshi, Hiroyuki

AU - Iwabuchi, Yoshiharu

AU - Yokosuka, Akihito

AU - Mimaki, Yoshihiro

AU - Naganuma, Akira

AU - Ohizumi, Yasushi

AU - Tomioka, Yoshihisa

AU - Yamakuni, Tohru

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AB - We recently demonstrated that nobiletin, a citrus flavonoid, exhibits anti-dementia action in animals. However, no determination methods for the content of nobiletin with beneficial action in the brain of nobiletin- administered animals have been developed, nor has its pharmacokinetics been revealed completely. Here, we established the high-performance liquid chromatography/photodiode array detection method for nobiletin determination using Bond Elut C18 SPE cartridges for extraction, where the calibration curve was linear over 0.025-10 ng, with coefficient of variation of less than 6.76%. This method enabled us to determine pharmacokinetic parameters of nobiletin given intraperitoneally or per os in the brain of mice.

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KW - Pharmacokinetics

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High-performance liquid chromatography with photodiode array detection for determination of nobiletin content in the brain and serum of mice administrated the natural compound

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