High performance optical resolution with liposome immobilized hydrogel

Takaaki Ishigami, Kazuma Sugita, Keishi Suga, Yukihiro Okamoto, Hiroshi Umakoshi

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


We prepared liposome immobilized hydrogels (LI-gels) for analysis and separation of chiral molecules, to overcome the drawbacks of liposomes such as low stability, and difficulties with handling and isolation from sample solutions. The amounts of liposomes in the hydrogels were larger than those in other solid matrices reported previously. The liposome morphology was intact, and its original properties, such as fluidity and phase transition behaviors, were preserved. We investigated the chiral recognition performance of the LI-gel, as described in our previous paper. Our results indicate that the enantioselectivity of the LI-gel was higher than those of conventional methods and of the liposomes alone. Our prepared LI-gel therefore overcomes the drawbacks of liposomes, and has potential applications in analysis and separation, including chiral separation.

Original languageEnglish
Pages (from-to)256-261
Number of pages6
JournalColloids and Surfaces B: Biointerfaces
Publication statusPublished - 2015 Dec 1


  • Hydrogel
  • Liposome
  • Optical resolution
  • Tryptophan


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