High-speed chemical imaging inside a microfluidic channel

Ko Ichiro Miyamoto, Akinori Itabashi, Torsten Wagner, Michael J. Schöning, Tatsuo Yoshinobu

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)


In this study, a high-speed chemical imaging system was developed for visualization of the interior of a microfluidic channel. A microfluidic channel was constructed on the sensor surface of the light-addressable potentiometric sensor (LAPS), on which the ion concentrations could be measured in parallel at up to 64 points illuminated by optical fibers. The temporal change of pH distribution inside the microfluidic channel was recorded at a maximum rate of 100 frames per second (fps). The high frame rate allowed visualization of moving interfaces and plugs in the channel even at a flow velocity of 111 mm/s, which suggests the feasibility of plug-based microfluidic devices for flow-injection analysis (FIA).

Original languageEnglish
Pages (from-to)521-527
Number of pages7
JournalSensors and Actuators B: Chemical
Publication statusPublished - 2014 Apr


  • High-speed chemical imaging
  • Light-addressable potentiometric sensor
  • Microfluidic channel


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