High-yielding synthesis of the anti-influenza neuramidase inhibitor (-)-oseltamivir by three "One-Pot" operations

Hayato Ishikawa, Takaki Suzuki, Yujiro Hayashi

Research output: Contribution to journalArticlepeer-review

356 Citations (Scopus)


Taking shortcuts: A remarkably short and high-yielding asymmetric total synthesis of (-)-oseltamivir takes advantage of organocatalysis and single-pot domino operations. The target, known as the drug Tamiflu, is prepared efficiently in a short time, and also its derivatives can be synthesized effectively.

Original languageEnglish
Pages (from-to)1304-1307
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number7
Publication statusPublished - 2009 Feb 2


  • Antiviral agents
  • Domino reactions
  • Organocatalysis
  • Oseltamivir
  • Tamiflu

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