Highly sensitive detection of catecholamine with interdigitated array microelectrodes in HPLC

Masaya Takahashi; Masao Morita; Osamu Niwa; Hisao Tabei

doi:10.1016/0925-4005(93)85395-Q

Highly sensitive detection of catecholamine with interdigitated array microelectrodes in HPLC

Masaya Takahashi, Masao Morita, Osamu Niwa, Hisao Tabei

Research output: Contribution to journal › Article › peer-review

Abstract

The highly sensitive detection of catecholamine has been achieved by using an interdigitated array (IDA) microelectrode as an electrochemical detector in a microbore high-performance liquid chromatography (HPLC) system. The current responses for catecholamine are measured for IDA electrodes with different gaps between their adjacent band electrodes. An IDA electrode with a narrow gap produces a high current density and reduces the influence of the auxiliary electrode position on the current response. The current response measured for an IDA electrode incorporated in the microbore HPLC system is about four times greater than that measured for a combination of the same IDA electrode and an ordinary sized column due to current enhancement by redox cycling in the slower stream.

Original language	English
Pages (from-to)	336-339
Number of pages	4
Journal	Sensors and Actuators: B. Chemical
Volume	13
Issue number	1-3
DOIs	https://doi.org/10.1016/0925-4005(93)85395-Q
Publication status	Published - 1993 Jan 1
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Electrochemistry
Electrical and Electronic Engineering

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abstract = "The highly sensitive detection of catecholamine has been achieved by using an interdigitated array (IDA) microelectrode as an electrochemical detector in a microbore high-performance liquid chromatography (HPLC) system. The current responses for catecholamine are measured for IDA electrodes with different gaps between their adjacent band electrodes. An IDA electrode with a narrow gap produces a high current density and reduces the influence of the auxiliary electrode position on the current response. The current response measured for an IDA electrode incorporated in the microbore HPLC system is about four times greater than that measured for a combination of the same IDA electrode and an ordinary sized column due to current enhancement by redox cycling in the slower stream.",

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AU - Morita, Masao

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AU - Tabei, Hisao

PY - 1993/1/1

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N2 - The highly sensitive detection of catecholamine has been achieved by using an interdigitated array (IDA) microelectrode as an electrochemical detector in a microbore high-performance liquid chromatography (HPLC) system. The current responses for catecholamine are measured for IDA electrodes with different gaps between their adjacent band electrodes. An IDA electrode with a narrow gap produces a high current density and reduces the influence of the auxiliary electrode position on the current response. The current response measured for an IDA electrode incorporated in the microbore HPLC system is about four times greater than that measured for a combination of the same IDA electrode and an ordinary sized column due to current enhancement by redox cycling in the slower stream.

AB - The highly sensitive detection of catecholamine has been achieved by using an interdigitated array (IDA) microelectrode as an electrochemical detector in a microbore high-performance liquid chromatography (HPLC) system. The current responses for catecholamine are measured for IDA electrodes with different gaps between their adjacent band electrodes. An IDA electrode with a narrow gap produces a high current density and reduces the influence of the auxiliary electrode position on the current response. The current response measured for an IDA electrode incorporated in the microbore HPLC system is about four times greater than that measured for a combination of the same IDA electrode and an ordinary sized column due to current enhancement by redox cycling in the slower stream.

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Highly sensitive detection of catecholamine with interdigitated array microelectrodes in HPLC

Abstract

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