Highly-sensitive magnetic sensor for detecting magnetic nanoparticles based on magnetic tunnel junctions at a low static field

Z. Jin; Thomas Myeongseok Koo; Myeong Soo Kim; M. Al-Mahdawi; M. Oogane; Y. Ando; Young Keun Kim

doi:10.1063/9.0000189

Highly-sensitive magnetic sensor for detecting magnetic nanoparticles based on magnetic tunnel junctions at a low static field

Z. Jin, Thomas Myeongseok Koo, Myeong Soo Kim, M. Al-Mahdawi, M. Oogane, Y. Ando, Young Keun Kim

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Magnetic sensors to detect magnetic nanoparticles (MNPs) towards biomedical applications require very high sensitivity at low magnetic fields. Here we report a magnetic sensor consisting of a magnetic tunnel junction (MTJ) with a synthetic antiferromagnetic free layer. This sensor exhibits a low magnetic anisotropy and sensitivities of over 18%/Oe at low fields in the range of 0 to 3 Oe. We employ superparamagnetic MNPs with a large diameter of 200 nm. The sensor's transfer curves show the magnetoresistance (MR) variations as a function of MNP concentration. We demonstrate the detection capability of MNP amounts of below 500 ng and low MNP concentrations of 0.01, 0.1, and 1 mg/ml in solvents. This result suggests that the combination of high-sensitivity TMR sensors and large MNPs has a substantial potential for biomarker detection applications.

Original language	English
Article number	015046
Journal	AIP Advances
Volume	11
Issue number	1
DOIs	https://doi.org/10.1063/9.0000189
Publication status	Published - 2021 Jan 1

ASJC Scopus subject areas

Physics and Astronomy(all)

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10.1063/9.0000189

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title = "Highly-sensitive magnetic sensor for detecting magnetic nanoparticles based on magnetic tunnel junctions at a low static field",

abstract = "Magnetic sensors to detect magnetic nanoparticles (MNPs) towards biomedical applications require very high sensitivity at low magnetic fields. Here we report a magnetic sensor consisting of a magnetic tunnel junction (MTJ) with a synthetic antiferromagnetic free layer. This sensor exhibits a low magnetic anisotropy and sensitivities of over 18%/Oe at low fields in the range of 0 to 3 Oe. We employ superparamagnetic MNPs with a large diameter of 200 nm. The sensor's transfer curves show the magnetoresistance (MR) variations as a function of MNP concentration. We demonstrate the detection capability of MNP amounts of below 500 ng and low MNP concentrations of 0.01, 0.1, and 1 mg/ml in solvents. This result suggests that the combination of high-sensitivity TMR sensors and large MNPs has a substantial potential for biomarker detection applications.",

author = "Z. Jin and Koo, {Thomas Myeongseok} and Kim, {Myeong Soo} and M. Al-Mahdawi and M. Oogane and Y. Ando and Kim, {Young Keun}",

note = "Funding Information: This research was supported by the S-Innovation program, the Japan Science and Technology Agency (JST, 201106007), the Center for Innovative Integrated Electronic System (CIES), the Center for Spintronics Research Network (CSRN), and the Organization for Advanced Studies, Center for Science and Innovation in Spintronics, the National Research Foundation of Korea (2019R1A2C3006587) and the Korea Evaluation Institute of Industrial Technology (10080408). Publisher Copyright: {\textcopyright} 2021 Author(s).",

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doi = "10.1063/9.0000189",

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AU - Jin, Z.

AU - Koo, Thomas Myeongseok

AU - Kim, Myeong Soo

AU - Al-Mahdawi, M.

AU - Oogane, M.

AU - Ando, Y.

AU - Kim, Young Keun

N1 - Funding Information: This research was supported by the S-Innovation program, the Japan Science and Technology Agency (JST, 201106007), the Center for Innovative Integrated Electronic System (CIES), the Center for Spintronics Research Network (CSRN), and the Organization for Advanced Studies, Center for Science and Innovation in Spintronics, the National Research Foundation of Korea (2019R1A2C3006587) and the Korea Evaluation Institute of Industrial Technology (10080408). Publisher Copyright: © 2021 Author(s).

PY - 2021/1/1

Y1 - 2021/1/1

N2 - Magnetic sensors to detect magnetic nanoparticles (MNPs) towards biomedical applications require very high sensitivity at low magnetic fields. Here we report a magnetic sensor consisting of a magnetic tunnel junction (MTJ) with a synthetic antiferromagnetic free layer. This sensor exhibits a low magnetic anisotropy and sensitivities of over 18%/Oe at low fields in the range of 0 to 3 Oe. We employ superparamagnetic MNPs with a large diameter of 200 nm. The sensor's transfer curves show the magnetoresistance (MR) variations as a function of MNP concentration. We demonstrate the detection capability of MNP amounts of below 500 ng and low MNP concentrations of 0.01, 0.1, and 1 mg/ml in solvents. This result suggests that the combination of high-sensitivity TMR sensors and large MNPs has a substantial potential for biomarker detection applications.

AB - Magnetic sensors to detect magnetic nanoparticles (MNPs) towards biomedical applications require very high sensitivity at low magnetic fields. Here we report a magnetic sensor consisting of a magnetic tunnel junction (MTJ) with a synthetic antiferromagnetic free layer. This sensor exhibits a low magnetic anisotropy and sensitivities of over 18%/Oe at low fields in the range of 0 to 3 Oe. We employ superparamagnetic MNPs with a large diameter of 200 nm. The sensor's transfer curves show the magnetoresistance (MR) variations as a function of MNP concentration. We demonstrate the detection capability of MNP amounts of below 500 ng and low MNP concentrations of 0.01, 0.1, and 1 mg/ml in solvents. This result suggests that the combination of high-sensitivity TMR sensors and large MNPs has a substantial potential for biomarker detection applications.

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Highly-sensitive magnetic sensor for detecting magnetic nanoparticles based on magnetic tunnel junctions at a low static field

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