Hippocampal-medial entorhinal circuit is differently organized along the dorsoventral axis in rodents

Shinya Ohara, Märt Rannap, Ken Ichiro Tsutsui, Andreas Draguhn, Alexei V. Egorov, Menno P. Witter

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

The general understanding of hippocampal circuits is that the hippocampus and the entorhinal cortex (EC) are topographically connected through parallel identical circuits along the dorsoventral axis. Our anterograde tracing and in vitro electrophysiology data, however, show a markedly different dorsoventral organization of the hippocampal projection to the medial EC (MEC). While dorsal hippocampal projections are confined to the dorsal MEC, ventral hippocampal projections innervate both dorsal and ventral MEC. Further, whereas the dorsal hippocampus preferentially targets layer Vb (LVb) neurons, the ventral hippocampus mainly targets cells in layer Va (LVa). This connectivity scheme differs from hippocampal projections to the lateral EC, which are topographically organized along the dorsoventral axis. As LVa neurons project to telencephalic structures, our findings indicate that the ventral hippocampus regulates LVa-mediated entorhinal-neocortical output from both dorsal and ventral MEC. Overall, the marked dorsoventral differences in hippocampal-entorhinal connectivity impose important constraints on signal flow in hippocampal-neocortical circuits.

Original languageEnglish
Article number112001
JournalCell Reports
Volume42
Issue number1
DOIs
Publication statusPublished - 2023 Jan 31

Keywords

  • CP: Neuroscience
  • anterograde tracing
  • dorsoventral axis
  • electrophysiology
  • hippocampal area CA1
  • hippocampal output circuit
  • lateral entorhinal cortex
  • layer V
  • medial entorhinal cortex
  • rodents
  • subiculum

Fingerprint

Dive into the research topics of 'Hippocampal-medial entorhinal circuit is differently organized along the dorsoventral axis in rodents'. Together they form a unique fingerprint.

Cite this