Histamine-induced, central nervous system-mediated hyperglycemia is suppressed by atropine in the brain

Katsunori Nonogaki; Li Xianzhu; Tatsuo Tamagawa; Genichi Watanabe; Yasuo Hiyoshi; Kuniaki Ozawa; Nobuo Sakamoto; Akihisa Iguchi

doi:10.1016/S0024-3205(05)80024-4

Histamine-induced, central nervous system-mediated hyperglycemia is suppressed by atropine in the brain

Katsunori Nonogaki, Li Xianzhu, Tatsuo Tamagawa, Genichi Watanabe, Yasuo Hiyoshi, Kuniaki Ozawa, Nobuo Sakamoto, Akihisa Iguchi

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

We investigated the relationship between histamine and muscarinic cholinergic neurons in central nervous system (CNS)—mediated glucose regulation in anesthetized fed rats. The injection of pyrilamine (5×10⁻⁷ mol) into the third cerebral ventricle suppressed the hyperglycemia induced by intraventricular injection of histamine (5×10⁻⁷ mol). Ranitidine (5×10⁻⁷ mol), however, did not suppress this hyperglycemia. The injection of atropine (5×10⁻⁹−5×10⁻⁷ mol) into the third cerebral ventricle suppressed the histamine-induced hyperglycemia in a dose-dependent manner. These findings suggest that histamine induction of CNS-mediated hyperglycemia involves neuronal transmission not only via H₁ receptors but also, at least in part, by muscarinic cholinergic neurons.

Original language	English
Pages (from-to)	PL-107-PL-110
Journal	Life Sciences
Volume	52
Issue number	15
DOIs	https://doi.org/10.1016/S0024-3205(05)80024-4
Publication status	Published - 1993
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/S0024-3205(05)80024-4

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title = "Histamine-induced, central nervous system-mediated hyperglycemia is suppressed by atropine in the brain",

abstract = "We investigated the relationship between histamine and muscarinic cholinergic neurons in central nervous system (CNS)—mediated glucose regulation in anesthetized fed rats. The injection of pyrilamine (5×10−7 mol) into the third cerebral ventricle suppressed the hyperglycemia induced by intraventricular injection of histamine (5×10−7 mol). Ranitidine (5×10−7 mol), however, did not suppress this hyperglycemia. The injection of atropine (5×10−9−5×10−7 mol) into the third cerebral ventricle suppressed the histamine-induced hyperglycemia in a dose-dependent manner. These findings suggest that histamine induction of CNS-mediated hyperglycemia involves neuronal transmission not only via H1 receptors but also, at least in part, by muscarinic cholinergic neurons.",

author = "Katsunori Nonogaki and Li Xianzhu and Tatsuo Tamagawa and Genichi Watanabe and Yasuo Hiyoshi and Kuniaki Ozawa and Nobuo Sakamoto and Akihisa Iguchi",

year = "1993",

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T1 - Histamine-induced, central nervous system-mediated hyperglycemia is suppressed by atropine in the brain

AU - Nonogaki, Katsunori

AU - Xianzhu, Li

AU - Tamagawa, Tatsuo

AU - Watanabe, Genichi

AU - Hiyoshi, Yasuo

AU - Ozawa, Kuniaki

AU - Sakamoto, Nobuo

AU - Iguchi, Akihisa

PY - 1993

Y1 - 1993

N2 - We investigated the relationship between histamine and muscarinic cholinergic neurons in central nervous system (CNS)—mediated glucose regulation in anesthetized fed rats. The injection of pyrilamine (5×10−7 mol) into the third cerebral ventricle suppressed the hyperglycemia induced by intraventricular injection of histamine (5×10−7 mol). Ranitidine (5×10−7 mol), however, did not suppress this hyperglycemia. The injection of atropine (5×10−9−5×10−7 mol) into the third cerebral ventricle suppressed the histamine-induced hyperglycemia in a dose-dependent manner. These findings suggest that histamine induction of CNS-mediated hyperglycemia involves neuronal transmission not only via H1 receptors but also, at least in part, by muscarinic cholinergic neurons.

AB - We investigated the relationship between histamine and muscarinic cholinergic neurons in central nervous system (CNS)—mediated glucose regulation in anesthetized fed rats. The injection of pyrilamine (5×10−7 mol) into the third cerebral ventricle suppressed the hyperglycemia induced by intraventricular injection of histamine (5×10−7 mol). Ranitidine (5×10−7 mol), however, did not suppress this hyperglycemia. The injection of atropine (5×10−9−5×10−7 mol) into the third cerebral ventricle suppressed the histamine-induced hyperglycemia in a dose-dependent manner. These findings suggest that histamine induction of CNS-mediated hyperglycemia involves neuronal transmission not only via H1 receptors but also, at least in part, by muscarinic cholinergic neurons.

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Histamine-induced, central nervous system-mediated hyperglycemia is suppressed by atropine in the brain

Abstract

ASJC Scopus subject areas

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