Hollow fiber-optic probe for in vivo Raman measurements

Takashi Katagiri, Yusuke Hattori, Yuichi Komachi, Yuji Matsuura, Hideo Tashiro, Hidetoshi Sato

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Citation (Scopus)


A hollow optical fiber (HOF) Roman probe equipped with a ball lens is developed to study the stomach cancer. The probe generates little Raman scattering or fluorescence noise because the HOF confine light into the air core. In order to maximize the collection efficiency and the spatial resolution, material and size of the ball lens is optimized. The total diameter of the probe head is 640 μm. The probe is useful for measurement of layered sample by the contact mode because it has very short focal length and high depth resolution. In vivo experiments in a stomach of a living rat demonstrate the high viability of the probe for noninvasive diagnosis of the stomach cancer.

Original languageEnglish
Title of host publicationSmart Medical and Biomedical Sensor Technology IV
Publication statusPublished - 2006
EventSmart Medical and Biomedical Sensor Technology IV - Boston, MA, United States
Duration: 2006 Oct 32006 Oct 4

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X


ConferenceSmart Medical and Biomedical Sensor Technology IV
Country/TerritoryUnited States
CityBoston, MA


  • Confocal
  • Hollow optical fiber
  • Optical biopsy
  • Raman spectroscopy


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