Hollow-waveguide-based laser-to-ultrasound transducer for drug delivery application

Shunichi Sato, Makoto Ogura, Minoru Obara, Yi Wei Shi, Yuji Matsuura, Mitsunobu Miyagi, Hiroshi Ashida

Research output: Contribution to journalConference articlepeer-review

2 Citations (Scopus)


A COP (cyclic olefin polymer)-coated silver hollow waveguide was used to transmit 1064-nm nanosecond laser pulses that irradiated a metal target to produce an ultrasound wave (stress wave) through a plasma formation on the target. Porcine gastric and myocardium tissues, on which a solution of rhodamine-B isothiocyanate-dextran (10 kDa) was dropped, were exposed to the stress wave. Much deeper drug penetration was observed for the tissues exposed the stress wave than for the tissues without stress wave exposure.

Original languageEnglish
Pages (from-to)207-211
Number of pages5
JournalProceedings of SPIE - The International Society for Optical Engineering
Publication statusPublished - 2002
EventOptical Fibers and Sensors for Medical Applications II - San Jose, CA, United States
Duration: 2002 Jan 222002 Jan 23


  • Drug delivery
  • Hollow waveguide
  • Nanosecond laser pulse
  • Porcine tissue
  • Rhodamine-B isothiocyanate-dextran
  • Stress wave
  • Ultrasound


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