HSP70 inducers from Chinese herbs and their effect on melanin production

Yasuhiro Yamashita; Tatsuya Hoshino; Minoru Matsuda; Chisa Kobayashi; Aya Tominaga; Yasuhiko Nakamura; Koumei Nakashima; Kazumi Yokomizo; Tsuyoshi Ikeda; Kazutaka Mineda; Daisuke Maji; Yoshimi Niwano; Tohru Mizushima

doi:10.1111/j.1600-0625.2009.01061.x

HSP70 inducers from Chinese herbs and their effect on melanin production

Yasuhiro Yamashita, Tatsuya Hoshino, Minoru Matsuda, Chisa Kobayashi, Aya Tominaga, Yasuhiko Nakamura, Koumei Nakashima, Kazumi Yokomizo, Tsuyoshi Ikeda, Kazutaka Mineda, Daisuke Maji, Yoshimi Niwano, Tohru Mizushima

Dentistry

Research output: Contribution to journal › Letter › peer-review

10 Citations (Scopus)

Abstract

Skin hyperpigmentation disorders as a result of abnormal melanin production induced by ultraviolet (UV) irradiation are both a clinical and a cosmetic problem. This melanin production is mediated by tyrosinase whose expression is positively regulated by microphthalmia-associated transcription factor (MITF). We recently found that expression of heat shock protein 70 (HSP70) inhibits melanin production. In this study, we searched for HSP70 inducers from Chinese herbs and selected an ethanol extract of Eupatorium lindleyanum (E. lindleyanum). Not only melanin production but also the activity and expression of tyrosinase were significantly suppressed in cells treated with E. lindleyanum extract as well as in HSP70-overexpressing cells. The expression of MITF was clearly suppressed in cells treated with E. lindleyanum extract but not in HSP70-overexpressing cells. These results suggest that E. lindleyanum extract suppresses the expression of tyrosinase and melanin production through both HSP70-dependent and HSP70-independent mechanisms.

Original language	English
Pages (from-to)	e340-e342
Journal	Experimental Dermatology
Volume	19
Issue number	8
DOIs	https://doi.org/10.1111/j.1600-0625.2009.01061.x
Publication status	Published - 2010 Aug

Keywords

Eupatorium lindleyanum
HSP70
MITF
Melanogenesis

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Dermatology

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10.1111/j.1600-0625.2009.01061.x

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title = "HSP70 inducers from Chinese herbs and their effect on melanin production",

abstract = "Skin hyperpigmentation disorders as a result of abnormal melanin production induced by ultraviolet (UV) irradiation are both a clinical and a cosmetic problem. This melanin production is mediated by tyrosinase whose expression is positively regulated by microphthalmia-associated transcription factor (MITF). We recently found that expression of heat shock protein 70 (HSP70) inhibits melanin production. In this study, we searched for HSP70 inducers from Chinese herbs and selected an ethanol extract of Eupatorium lindleyanum (E. lindleyanum). Not only melanin production but also the activity and expression of tyrosinase were significantly suppressed in cells treated with E. lindleyanum extract as well as in HSP70-overexpressing cells. The expression of MITF was clearly suppressed in cells treated with E. lindleyanum extract but not in HSP70-overexpressing cells. These results suggest that E. lindleyanum extract suppresses the expression of tyrosinase and melanin production through both HSP70-dependent and HSP70-independent mechanisms.",

keywords = "Eupatorium lindleyanum, HSP70, MITF, Melanogenesis",

author = "Yasuhiro Yamashita and Tatsuya Hoshino and Minoru Matsuda and Chisa Kobayashi and Aya Tominaga and Yasuhiko Nakamura and Koumei Nakashima and Kazumi Yokomizo and Tsuyoshi Ikeda and Kazutaka Mineda and Daisuke Maji and Yoshimi Niwano and Tohru Mizushima",

year = "2010",

month = aug,

doi = "10.1111/j.1600-0625.2009.01061.x",

language = "English",

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T1 - HSP70 inducers from Chinese herbs and their effect on melanin production

AU - Yamashita, Yasuhiro

AU - Hoshino, Tatsuya

AU - Matsuda, Minoru

AU - Kobayashi, Chisa

AU - Tominaga, Aya

AU - Nakamura, Yasuhiko

AU - Nakashima, Koumei

AU - Yokomizo, Kazumi

AU - Ikeda, Tsuyoshi

AU - Mineda, Kazutaka

AU - Maji, Daisuke

AU - Niwano, Yoshimi

AU - Mizushima, Tohru

PY - 2010/8

Y1 - 2010/8

N2 - Skin hyperpigmentation disorders as a result of abnormal melanin production induced by ultraviolet (UV) irradiation are both a clinical and a cosmetic problem. This melanin production is mediated by tyrosinase whose expression is positively regulated by microphthalmia-associated transcription factor (MITF). We recently found that expression of heat shock protein 70 (HSP70) inhibits melanin production. In this study, we searched for HSP70 inducers from Chinese herbs and selected an ethanol extract of Eupatorium lindleyanum (E. lindleyanum). Not only melanin production but also the activity and expression of tyrosinase were significantly suppressed in cells treated with E. lindleyanum extract as well as in HSP70-overexpressing cells. The expression of MITF was clearly suppressed in cells treated with E. lindleyanum extract but not in HSP70-overexpressing cells. These results suggest that E. lindleyanum extract suppresses the expression of tyrosinase and melanin production through both HSP70-dependent and HSP70-independent mechanisms.

AB - Skin hyperpigmentation disorders as a result of abnormal melanin production induced by ultraviolet (UV) irradiation are both a clinical and a cosmetic problem. This melanin production is mediated by tyrosinase whose expression is positively regulated by microphthalmia-associated transcription factor (MITF). We recently found that expression of heat shock protein 70 (HSP70) inhibits melanin production. In this study, we searched for HSP70 inducers from Chinese herbs and selected an ethanol extract of Eupatorium lindleyanum (E. lindleyanum). Not only melanin production but also the activity and expression of tyrosinase were significantly suppressed in cells treated with E. lindleyanum extract as well as in HSP70-overexpressing cells. The expression of MITF was clearly suppressed in cells treated with E. lindleyanum extract but not in HSP70-overexpressing cells. These results suggest that E. lindleyanum extract suppresses the expression of tyrosinase and melanin production through both HSP70-dependent and HSP70-independent mechanisms.

KW - Eupatorium lindleyanum

KW - HSP70

KW - MITF

KW - Melanogenesis

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HSP70 inducers from Chinese herbs and their effect on melanin production

Abstract

Keywords

ASJC Scopus subject areas

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