Hub promiscuity in protein-protein interaction networks

Ashwini Patil, Kengo Kinoshita, Haruki Nakamura

Research output: Contribution to journalReview articlepeer-review

124 Citations (Scopus)


Hubs are proteins with a large number of interactions in a protein-protein interaction network. They are the principal agents in the interaction network and affect its function and stability. Their specific recognition of many different protein partners is of great interest from the structural viewpoint. Over the last few years, the structural properties of hubs have been extensively studied. We review the currently known features that are particular to hubs, possibly affecting their binding ability. Specifically, we look at the levels of intrinsic disorder, surface charge and domain distribution in hubs, as compared to non-hubs, along with differences in their functional domains.

Original languageEnglish
Pages (from-to)1930-1943
Number of pages14
JournalInternational Journal of Molecular Sciences
Issue number4
Publication statusPublished - 2010 Apr


  • Hubs
  • Interaction networks
  • Promiscuous binding
  • Protein-protein interactions


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