Hydration of single-stranded DNA in water studied by infrared spectroscopy

Ko ichiro Miyamoto, Kota Onodera, Ryo taro Yamaguchi, Ken ichi Ishibashi, Yasuo Kimura, Michio Niwano

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Hydration of single-stranded DNAs (oligonucleotides) of thymine (dT10) and adenine (dA10) in heavy water has been investigated using infrared absorption spectroscopy in the geometry of multiple internal reflection. Comparison of infrared absorption data with results of ab initio cluster calculation clearly indicates that water molecules are bound to the C{double bond, long}O and N-H bonds of the thymine base, giving rise to a red-shift of the C{double bond, long}O stretching vibration modes, and that the water molecule is site-specifically bound to the thymine base. We find that hydration induces a blue-shift of the ring deformation mode of the adenine base.

Original languageEnglish
Pages (from-to)233-238
Number of pages6
JournalChemical Physics Letters
Issue number1-3
Publication statusPublished - 2007 Feb 27


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