TY - JOUR
T1 - Hydrogel-Based Organic Subdural Electrode with High Conformability to Brain Surface
AU - Oribe, Shuntaro
AU - Yoshida, Shotaro
AU - Kusama, Shinya
AU - Osawa, Shin ichiro
AU - Nakagawa, Atsuhiro
AU - Iwasaki, Masaki
AU - Tominaga, Teiji
AU - Nishizawa, Matsuhiko
N1 - Funding Information:
This work was partly supported by AMED-SENTAN (18065130) from Japan Agency for Medical Research and Development (AMED) and Grand-in-Aid for Scientific Research A (25246016) (18H04157), Scientific Research B (19H03755), Scientific Research C (19K08090) (18K08932) (18K08960) (18K08561) (17K11373) (16K10780) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan. We also acknowledge Prof. Keiko Numayama-Tsuruta and Dr. Aki Nunomiya at the Graduate School of Biomedical Engineering at Tohoku University for help with MRI imaging, Emiko Kaneda at Department of Neurosurgery, Tohoku University Graduate School of Medicine for administrative assistance, and Li Jiun Chen at Tohoku University for helpful discussion.
Publisher Copyright:
© 2019, The Author(s).
PY - 2019/12/1
Y1 - 2019/12/1
N2 - A totally soft organic subdural electrode has been developed by embedding an array of poly(3,4-ethylenedioxythiophene)-modified carbon fabric (PEDOT-CF) into the polyvinyl alcohol (PVA) hydrogel substrate. The mesh structure of the stretchable PEDOT-CF allowed stable structural integration with the PVA substrate. The electrode performance for monitoring electrocorticography (ECoG) was evaluated in saline solution, on ex vivo brains, and in vivo animal experiments using rats and porcines. It was demonstrated that the large double-layer capacitance of the PEDOT-CF brings low impedance at the frequency of brain wave including epileptic seizures, and PVA hydrogel substrate minimized the contact impedance on the brain. The most important unique feature of the hydrogel-based ECoG electrode was its shape conformability to enable tight adhesion even to curved, grooved surface of brains by just being placed. In addition, since the hydrogel-based electrode is totally organic, the simultaneous ECoG-fMRI measurements could be conducted without image artifacts, avoiding problems induced by conventional metallic electrodes.
AB - A totally soft organic subdural electrode has been developed by embedding an array of poly(3,4-ethylenedioxythiophene)-modified carbon fabric (PEDOT-CF) into the polyvinyl alcohol (PVA) hydrogel substrate. The mesh structure of the stretchable PEDOT-CF allowed stable structural integration with the PVA substrate. The electrode performance for monitoring electrocorticography (ECoG) was evaluated in saline solution, on ex vivo brains, and in vivo animal experiments using rats and porcines. It was demonstrated that the large double-layer capacitance of the PEDOT-CF brings low impedance at the frequency of brain wave including epileptic seizures, and PVA hydrogel substrate minimized the contact impedance on the brain. The most important unique feature of the hydrogel-based ECoG electrode was its shape conformability to enable tight adhesion even to curved, grooved surface of brains by just being placed. In addition, since the hydrogel-based electrode is totally organic, the simultaneous ECoG-fMRI measurements could be conducted without image artifacts, avoiding problems induced by conventional metallic electrodes.
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U2 - 10.1038/s41598-019-49772-z
DO - 10.1038/s41598-019-49772-z
M3 - Article
C2 - 31527626
AN - SCOPUS:85072267131
SN - 2045-2322
VL - 9
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 13379
ER -