Hydroxyapatite formation on porous ceramics of alpha-tricalcium phosphate in a simulated body fluid

Tomohiro Uchino, Kohei Yamaguchi, Ichiro Suzuki, Masanobu Kamitakahara, Makoto Otsuka, Chikara Ohtsuki

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


Alpha-tricalcium phosphate (α-TCP) ceramic is a bioresorbable material that degrades in bone tissue after implantation, since it exhibits higher solubility than beta-tricalcium phosphate (β-TCP) ceramics. The high solubility of α-TCP in an aqueous solution causes its transformation into hydroxyapatite (HAp) through hydrolysis. While one expects the formation of hydroxyapatite after exposure to an aqueous solution mimicking a body environment, we occasionally find variation in HAp formation in the simulated body fluid (SBF). In the present study, HAp formation resulting from exposure to SBF was investigated for some types of α-TCP ceramics with different porosities and specific surface area. Reduced porosity and large surface area of porous specimens may increase the local density of Ca 2+ in the surrounding SBF to increase the degree of supersaturation with respect to HAp. Thus, the porosity and specific surface area are significant parameters for determining not only bioabsorbability but also the ability to form HAp.

Original languageEnglish
Pages (from-to)1921-1926
Number of pages6
JournalJournal of Materials Science: Materials in Medicine
Issue number6
Publication statusPublished - 2010 Jun 1

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering


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