Hyperglycemia induced by hippocampal administration of neostigmine is suppressed by intrahypothalamic atropine

A. Iguchi; K. Uemura; Y. Kunoh; H. Miura; T. Ishiguro; K. Nonogaki; T. Tamagawa; M. Gotoh; N. Sakamoto

doi:10.1016/0028-3908(91)90144-Z

Hyperglycemia induced by hippocampal administration of neostigmine is suppressed by intrahypothalamic atropine

A. Iguchi, K. Uemura, Y. Kunoh, H. Miura, T. Ishiguro, K. Nonogaki, T. Tamagawa, M. Gotoh, N. Sakamoto

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

We investigated the relationship between the hyperglycemia induced by the administration of neostigmine into the hippocampus and the hypothalamus. Prior to the injection of neostigmine (5×10^-8 mol) into the hippocampus, 1 μl each of atropine or hexamethonium (5×10^-11-5×10^-8 mol) was injected into the bilateral ventromedial hypothalamus (VMH). Atropine suppressed in a dose-dependent manner the hyperglycemia induced by hippocampal administration of neostigmine, whereas hexamethonium had no significant effect. These observations suggest that the pathway for this experimental hyperglycemia involves, at least in part, the muscarinic cholinergic neurons in the VMH.

Original language	English
Pages (from-to)	1129-1131
Number of pages	3
Journal	Neuropharmacology
Volume	30
Issue number	10
DOIs	https://doi.org/10.1016/0028-3908(91)90144-Z
Publication status	Published - 1991 Oct
Externally published	Yes

Keywords

blood glucose
cholinergic
hippocampus
hypothalamus

ASJC Scopus subject areas

Pharmacology
Cellular and Molecular Neuroscience

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10.1016/0028-3908(91)90144-Z

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title = "Hyperglycemia induced by hippocampal administration of neostigmine is suppressed by intrahypothalamic atropine",

abstract = "We investigated the relationship between the hyperglycemia induced by the administration of neostigmine into the hippocampus and the hypothalamus. Prior to the injection of neostigmine (5×10-8 mol) into the hippocampus, 1 μl each of atropine or hexamethonium (5×10-11-5×10-8 mol) was injected into the bilateral ventromedial hypothalamus (VMH). Atropine suppressed in a dose-dependent manner the hyperglycemia induced by hippocampal administration of neostigmine, whereas hexamethonium had no significant effect. These observations suggest that the pathway for this experimental hyperglycemia involves, at least in part, the muscarinic cholinergic neurons in the VMH.",

keywords = "blood glucose, cholinergic, hippocampus, hypothalamus",

author = "A. Iguchi and K. Uemura and Y. Kunoh and H. Miura and T. Ishiguro and K. Nonogaki and T. Tamagawa and M. Gotoh and N. Sakamoto",

year = "1991",

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doi = "10.1016/0028-3908(91)90144-Z",

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T1 - Hyperglycemia induced by hippocampal administration of neostigmine is suppressed by intrahypothalamic atropine

AU - Iguchi, A.

AU - Uemura, K.

AU - Kunoh, Y.

AU - Miura, H.

AU - Ishiguro, T.

AU - Nonogaki, K.

AU - Tamagawa, T.

AU - Gotoh, M.

AU - Sakamoto, N.

PY - 1991/10

Y1 - 1991/10

N2 - We investigated the relationship between the hyperglycemia induced by the administration of neostigmine into the hippocampus and the hypothalamus. Prior to the injection of neostigmine (5×10-8 mol) into the hippocampus, 1 μl each of atropine or hexamethonium (5×10-11-5×10-8 mol) was injected into the bilateral ventromedial hypothalamus (VMH). Atropine suppressed in a dose-dependent manner the hyperglycemia induced by hippocampal administration of neostigmine, whereas hexamethonium had no significant effect. These observations suggest that the pathway for this experimental hyperglycemia involves, at least in part, the muscarinic cholinergic neurons in the VMH.

AB - We investigated the relationship between the hyperglycemia induced by the administration of neostigmine into the hippocampus and the hypothalamus. Prior to the injection of neostigmine (5×10-8 mol) into the hippocampus, 1 μl each of atropine or hexamethonium (5×10-11-5×10-8 mol) was injected into the bilateral ventromedial hypothalamus (VMH). Atropine suppressed in a dose-dependent manner the hyperglycemia induced by hippocampal administration of neostigmine, whereas hexamethonium had no significant effect. These observations suggest that the pathway for this experimental hyperglycemia involves, at least in part, the muscarinic cholinergic neurons in the VMH.

KW - blood glucose

KW - cholinergic

KW - hippocampus

KW - hypothalamus

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Hyperglycemia induced by hippocampal administration of neostigmine is suppressed by intrahypothalamic atropine

Abstract

Keywords

ASJC Scopus subject areas

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