Hyperosmolar hyperglycemic nonketotic coma after chemoradiotherapy for esophageal cancer

Toru Nakano, Go Miyata, Ko Onodera, Hirofumi Ichikawa, Takashi Kamei, Tohru Hoshida, Hiroshi Kikuchi, Keiichi Jingu, Noriaki Ohuchi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


A 73-year-old man was diagnosed with a type 2 tumor in the middle third of his esophagus by upper esophagogastrointestinal examination and an esophagogram; the tumor was diagnosed as squamous cell carcinoma by endoscopic biopsy. Computed tomography (CT) revealed that the tumor had invaded his descending aorta. He was diagnosed with T4b/N0/M0 stage IIIc [Union for International Cancer Control (UICC), 7th edition] esophageal cancer. He had no previous history of diabetes mellitus. We treated him with concurrent chemoradiotherapy using cisplatin and 5-fluorouracil. Fourteen days after the entire course of chemoradiotherapy, he became confused and entered into sudden coma, which was diagnosed as hyperosmolar hyperglycemic nonketotic coma. With vigorous intravenous infusion of half-saline and insulin, he recovered from the coma 36 h after onset. Hyperosmolar hyperglycemic nonketotic coma is a severe complication that is difficult to treat and can be induced by chemoradiotherapy. It must be diagnosed early and treated appropriately.

Original languageEnglish
Pages (from-to)273-276
Number of pages4
Issue number4
Publication statusPublished - 2014 Sept


  • 5-Fluorouracil
  • Chemotherapy
  • Cisplatin
  • Insulin
  • Radiation


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