Hypomethylation and expression of pepsinogen a genes in the fundic mucosa of human stomach

Masao Ichinose; Kazumasa Miki; Masae Tatematsu; Chie Furihata; Masahiro Nobuhara; Yoshikazu Ichihara; Masao Tanji; Kazuhiro Sogawa; Yoshiaki Fujii-Kuriyama; Hiroshi Oka; Takayuki Takahashi; Takashi Kageyama; Kenji Takahashi

doi:10.1016/0006-291X(88)90590-6

Hypomethylation and expression of pepsinogen a genes in the fundic mucosa of human stomach

Masao Ichinose, Kazumasa Miki, Masae Tatematsu, Chie Furihata, Masahiro Nobuhara, Yoshikazu Ichihara, Masao Tanji, Kazuhiro Sogawa, Yoshiaki Fujii-Kuriyama, Hiroshi Oka, Takayuki Takahashi, Takashi Kageyama, Kenji Takahashi

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

We have examined the correlation between the extents of methylation and expression of pepsinogen A genes in normal human tissues. Expression of pepsinogen A mRNA was detected only in the fundic mucosa of the stomach and both CCGG and GCGC sites in the tenes region were less methylated in the fundic mucosa than in other non-expressing tissues. Thus, there was an inverse correlation between the extents of methylation and expression of pepsinogen A genes and the role of DNA methylation in the regulation of pepsinogen A genes expression during normal differentiation was suggested.

Original language	English
Pages (from-to)	275-282
Number of pages	8
Journal	Biochemical and biophysical research communications
Volume	151
Issue number	1
DOIs	https://doi.org/10.1016/0006-291X(88)90590-6
Publication status	Published - 1988 Feb 29

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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Ichinose, M., Miki, K., Tatematsu, M., Furihata, C., Nobuhara, M., Ichihara, Y., Tanji, M., Sogawa, K., Fujii-Kuriyama, Y., Oka, H., Takahashi, T., Kageyama, T., & Takahashi, K. (1988). Hypomethylation and expression of pepsinogen a genes in the fundic mucosa of human stomach. Biochemical and biophysical research communications, 151(1), 275-282. https://doi.org/10.1016/0006-291X(88)90590-6

Ichinose, M, Miki, K, Tatematsu, M, Furihata, C, Nobuhara, M, Ichihara, Y, Tanji, M, Sogawa, K, Fujii-Kuriyama, Y, Oka, H, Takahashi, T, Kageyama, T & Takahashi, K 1988, 'Hypomethylation and expression of pepsinogen a genes in the fundic mucosa of human stomach', Biochemical and biophysical research communications, vol. 151, no. 1, pp. 275-282. https://doi.org/10.1016/0006-291X(88)90590-6

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abstract = "We have examined the correlation between the extents of methylation and expression of pepsinogen A genes in normal human tissues. Expression of pepsinogen A mRNA was detected only in the fundic mucosa of the stomach and both CCGG and GCGC sites in the tenes region were less methylated in the fundic mucosa than in other non-expressing tissues. Thus, there was an inverse correlation between the extents of methylation and expression of pepsinogen A genes and the role of DNA methylation in the regulation of pepsinogen A genes expression during normal differentiation was suggested.",

author = "Masao Ichinose and Kazumasa Miki and Masae Tatematsu and Chie Furihata and Masahiro Nobuhara and Yoshikazu Ichihara and Masao Tanji and Kazuhiro Sogawa and Yoshiaki Fujii-Kuriyama and Hiroshi Oka and Takayuki Takahashi and Takashi Kageyama and Kenji Takahashi",

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doi = "10.1016/0006-291X(88)90590-6",

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T1 - Hypomethylation and expression of pepsinogen a genes in the fundic mucosa of human stomach

AU - Ichinose, Masao

AU - Miki, Kazumasa

AU - Tatematsu, Masae

AU - Furihata, Chie

AU - Nobuhara, Masahiro

AU - Ichihara, Yoshikazu

AU - Tanji, Masao

AU - Sogawa, Kazuhiro

AU - Fujii-Kuriyama, Yoshiaki

AU - Oka, Hiroshi

AU - Takahashi, Takayuki

AU - Kageyama, Takashi

AU - Takahashi, Kenji

PY - 1988/2/29

Y1 - 1988/2/29

N2 - We have examined the correlation between the extents of methylation and expression of pepsinogen A genes in normal human tissues. Expression of pepsinogen A mRNA was detected only in the fundic mucosa of the stomach and both CCGG and GCGC sites in the tenes region were less methylated in the fundic mucosa than in other non-expressing tissues. Thus, there was an inverse correlation between the extents of methylation and expression of pepsinogen A genes and the role of DNA methylation in the regulation of pepsinogen A genes expression during normal differentiation was suggested.

AB - We have examined the correlation between the extents of methylation and expression of pepsinogen A genes in normal human tissues. Expression of pepsinogen A mRNA was detected only in the fundic mucosa of the stomach and both CCGG and GCGC sites in the tenes region were less methylated in the fundic mucosa than in other non-expressing tissues. Thus, there was an inverse correlation between the extents of methylation and expression of pepsinogen A genes and the role of DNA methylation in the regulation of pepsinogen A genes expression during normal differentiation was suggested.

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Hypomethylation and expression of pepsinogen a genes in the fundic mucosa of human stomach

Abstract

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