TY - JOUR
T1 - Hypopigmented mycosis fungoides
T2 - An immunological investigation of tumor-infiltrating T cells
AU - Nasu-Tababuchi, Mei
AU - Fujimura, Taku
AU - Kakizaki, Aya
AU - Shido, Kosuke
AU - Hatchome, Naokazu
AU - Kusakari, Yoshiyuki
AU - Aiba, Setsuya
N1 - Publisher Copyright:
© Copyright 2016, Taiwanese Dermatological Association. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Hypopigmented mycosis fungoides (HMF) is a clinical variant of MF presenting a good prognosis. In this report, we describe a case of HMF with dense infiltration of tumor-infiltrating leukocytes that bear several cytotoxic molecules, such as granulysin and T-cell intracellular antigen-1. In addition, our immunohistochemical study revealed that the ratio of Foxp3+ regulatory T cells to the total CD4+ cells is decreased in the lesional skin of HMF, compared with that of conventional MF. Our case suggested possible mechanisms for the hypopigmentation and good prognosis of this type of MF.
AB - Hypopigmented mycosis fungoides (HMF) is a clinical variant of MF presenting a good prognosis. In this report, we describe a case of HMF with dense infiltration of tumor-infiltrating leukocytes that bear several cytotoxic molecules, such as granulysin and T-cell intracellular antigen-1. In addition, our immunohistochemical study revealed that the ratio of Foxp3+ regulatory T cells to the total CD4+ cells is decreased in the lesional skin of HMF, compared with that of conventional MF. Our case suggested possible mechanisms for the hypopigmentation and good prognosis of this type of MF.
KW - cytotoxic molecules
KW - hypopigmented mycosis fungoides
KW - regulatory T cells
KW - tumor-infiltrating leukocytes
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U2 - 10.1016/j.dsi.2015.08.006
DO - 10.1016/j.dsi.2015.08.006
M3 - Article
AN - SCOPUS:84951320790
SN - 1027-8117
VL - 34
SP - 96
EP - 98
JO - Dermatologica Sinica
JF - Dermatologica Sinica
IS - 2
ER -