Hypoxia induces transcription factor ETS-1 via the activity of hypoxia-lnducible factor-1

Manami Oikawa, Mayumi Abe, Hajime Kurosawa, Wataru Hida, Kunio Shirato, Yasufumi Sato

Research output: Contribution to journalArticlepeer-review

136 Citations (Scopus)


ETS-1 plays an important role in angiogenesis and cancer invasion, and hypoxia is a common feature in these phenomena. We examined whether hypoxia influenced ETS-1 expression. Hypoxia induced ETS-1 in a human bladder cancer cell line, T24, and promoter analysis revealed that the deletion of -424 to -279 bp from the human ETS-1 promoter decreased the hypoxia-mediated inducibility. This region contained a hypoxia responsive element-like sequence, and HIF-1 bound to it under the hypoxic condition. Double-stranded synthetic oligonucleotides of this sequence as a decoy inhibited the hypoxia-mediated induciblity. These results indicate that hypoxia induces ETS-1 via the activity of HIF-1.

Original languageEnglish
Pages (from-to)39-43
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number1
Publication statusPublished - 2001 Nov 23


  • Angiogenesis
  • ETS-1
  • HIF-1
  • Hypoxia
  • Tumor invasion


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