Hypoxia induces transcription factor ETS-1 via the activity of hypoxia-lnducible factor-1

Manami Oikawa; Mayumi Abe; Hajime Kurosawa; Wataru Hida; Kunio Shirato; Yasufumi Sato

doi:10.1006/bbrc.2001.5927

Hypoxia induces transcription factor ETS-1 via the activity of hypoxia-lnducible factor-1

Manami Oikawa, Mayumi Abe, Hajime Kurosawa, Wataru Hida, Kunio Shirato, Yasufumi Sato

Tohoku University

Research output: Contribution to journal › Article › peer-review

136 Citations (Scopus)

Abstract

ETS-1 plays an important role in angiogenesis and cancer invasion, and hypoxia is a common feature in these phenomena. We examined whether hypoxia influenced ETS-1 expression. Hypoxia induced ETS-1 in a human bladder cancer cell line, T24, and promoter analysis revealed that the deletion of -424 to -279 bp from the human ETS-1 promoter decreased the hypoxia-mediated inducibility. This region contained a hypoxia responsive element-like sequence, and HIF-1 bound to it under the hypoxic condition. Double-stranded synthetic oligonucleotides of this sequence as a decoy inhibited the hypoxia-mediated induciblity. These results indicate that hypoxia induces ETS-1 via the activity of HIF-1.

Original language	English
Pages (from-to)	39-43
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	289
Issue number	1
DOIs	https://doi.org/10.1006/bbrc.2001.5927
Publication status	Published - 2001 Nov 23

Keywords

Angiogenesis
ETS-1
HIF-1
Hypoxia
Tumor invasion

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1006/bbrc.2001.5927

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title = "Hypoxia induces transcription factor ETS-1 via the activity of hypoxia-lnducible factor-1",

abstract = "ETS-1 plays an important role in angiogenesis and cancer invasion, and hypoxia is a common feature in these phenomena. We examined whether hypoxia influenced ETS-1 expression. Hypoxia induced ETS-1 in a human bladder cancer cell line, T24, and promoter analysis revealed that the deletion of -424 to -279 bp from the human ETS-1 promoter decreased the hypoxia-mediated inducibility. This region contained a hypoxia responsive element-like sequence, and HIF-1 bound to it under the hypoxic condition. Double-stranded synthetic oligonucleotides of this sequence as a decoy inhibited the hypoxia-mediated induciblity. These results indicate that hypoxia induces ETS-1 via the activity of HIF-1.",

keywords = "Angiogenesis, ETS-1, HIF-1, Hypoxia, Tumor invasion",

author = "Manami Oikawa and Mayumi Abe and Hajime Kurosawa and Wataru Hida and Kunio Shirato and Yasufumi Sato",

note = "Funding Information: This work was supported by the program Grants-in-Aid for Scientific Research on Priority Areas of the Japanese Ministry of Education, Science, Sports, and Culture (Contract No. 09281101).",

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doi = "10.1006/bbrc.2001.5927",

language = "English",

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T1 - Hypoxia induces transcription factor ETS-1 via the activity of hypoxia-lnducible factor-1

AU - Oikawa, Manami

AU - Abe, Mayumi

AU - Kurosawa, Hajime

AU - Hida, Wataru

AU - Shirato, Kunio

AU - Sato, Yasufumi

N1 - Funding Information: This work was supported by the program Grants-in-Aid for Scientific Research on Priority Areas of the Japanese Ministry of Education, Science, Sports, and Culture (Contract No. 09281101).

PY - 2001/11/23

Y1 - 2001/11/23

N2 - ETS-1 plays an important role in angiogenesis and cancer invasion, and hypoxia is a common feature in these phenomena. We examined whether hypoxia influenced ETS-1 expression. Hypoxia induced ETS-1 in a human bladder cancer cell line, T24, and promoter analysis revealed that the deletion of -424 to -279 bp from the human ETS-1 promoter decreased the hypoxia-mediated inducibility. This region contained a hypoxia responsive element-like sequence, and HIF-1 bound to it under the hypoxic condition. Double-stranded synthetic oligonucleotides of this sequence as a decoy inhibited the hypoxia-mediated induciblity. These results indicate that hypoxia induces ETS-1 via the activity of HIF-1.

AB - ETS-1 plays an important role in angiogenesis and cancer invasion, and hypoxia is a common feature in these phenomena. We examined whether hypoxia influenced ETS-1 expression. Hypoxia induced ETS-1 in a human bladder cancer cell line, T24, and promoter analysis revealed that the deletion of -424 to -279 bp from the human ETS-1 promoter decreased the hypoxia-mediated inducibility. This region contained a hypoxia responsive element-like sequence, and HIF-1 bound to it under the hypoxic condition. Double-stranded synthetic oligonucleotides of this sequence as a decoy inhibited the hypoxia-mediated induciblity. These results indicate that hypoxia induces ETS-1 via the activity of HIF-1.

KW - Angiogenesis

KW - ETS-1

KW - HIF-1

KW - Hypoxia

KW - Tumor invasion

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Hypoxia induces transcription factor ETS-1 via the activity of hypoxia-lnducible factor-1

Abstract

Keywords

UN SDGs

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