@inbook{6acdc2ede2d94e058adfde1fc6fe1d98,
title = "Iatrogenic Creutzfeldt–Jakob disease",
abstract = "Iatrogenic transmission of Creutzfeldt–Jakob disease (CJD) has occurred through particular medical procedures. Among them, dura mater grafts and pituitary-derived growth hormone obtained from human cadavers undiagnosed as CJD are the most frequent sources of infection. Recent advances in our knowledge about dura mater graft- and human pituitary-derived growth hormone-associated CJD patients have revealed that the combination of the infected CJD strain and the PRNP genotype of the patient determines their clinical, neuropathologic, and biochemical features. In this chapter, we summarize the clinical, neuropathologic, biochemical, and diagnostic features of dura mater graft- and human pituitary-derived growth hormone-associated CJD patients for the appropriate diagnosis of iatrogenic CJD.",
keywords = "Creutzfeldt–Jakob disease, M1 strain, V2 strain, acquired, dura mater graft, human pituitary-derived growth hormone, iatrogenic",
author = "Atsushi Kobayashi and Tetsuyuki Kitamoto and Hidehiro Mizusawa",
note = "Funding Information: We thank Brent Bell for critical review of the manuscript. The surveillance on CJD has been supported by Grants-in-Aid from the Ministry of Health, Labor and Welfare of Japan (TK and HM), and the experimental transmission study of iCJD was supported by Grants-in-Aid from the Ministry of Health, Labor and Welfare of Japan (AK and TK), Grants-in-Aid for Scientific Research from JSPS (AK and TK), a grant from MEXT for the Joint Research Program of the Research Center for Zoonosis Control, Hokkaido University (TK), and a Grant-in-Aid for Scientific Research on Innovative Areas (Brain Protein Aging and Dementia Control) from MEXT (TK). Publisher Copyright: {\textcopyright} 2018 Elsevier B.V.",
year = "2018",
doi = "10.1016/B978-0-444-63945-5.00012-X",
language = "English",
series = "Handbook of Clinical Neurology",
publisher = "Elsevier B.V.",
pages = "207--218",
booktitle = "Handbook of Clinical Neurology",
}
