Identification and sequence analysis of the Marek's disease virus serotype 2 gene homologous to the herpes simplex virus type 1 UL52 protein

Yoshihiro Izumiya; Hyung Kwan Jang; Jin Shun Cai; Yorihiro Nishimura; Kazuya Nakamura; Yoshinori Tsushima; Kentaro Kato; Takayuki Miyazawa; Chieko Kai; Takeshi Mikami

doi:10.1292/jvms.61.683

Identification and sequence analysis of the Marek's disease virus serotype 2 gene homologous to the herpes simplex virus type 1 UL52 protein

Yoshihiro Izumiya, Hyung Kwan Jang, Jin Shun Cai, Yorihiro Nishimura, Kazuya Nakamura, Yoshinori Tsushima, Kentaro Kato, Takayuki Miyazawa, Chieko Kai, Takeshi Mikami

Research output: Contribution to journal › Article › peer-review

Abstract

The gene of Marek's disease virus serotype 2 (MDV2) homologous to the UL52 gene of herpes simplex virus type 1 (HSV-1) was identified and characterized. The MDV2 UL52 homologous gene encodes 1,071 amino acids with a molecular weight of 118.7 kDa, which includes putative metal-binding site and overlapping region with the UL53 homologous gene. Although a putative polyadenylation signal sequence was found in the downstream of the MDV2 UL52 gene, a MDV2 UL52 DNA probe reacted only with the polycistronic 6.3 kb transcript, representing the UL52 and the downstream genes of UL53 and UL54. Transcriptional pattern of this region of MDV2 was somewhat different from corresponding regions of HSV-1 and infectious laryngotracheitis virus.

Original language	English
Pages (from-to)	683-687
Number of pages	5
Journal	Journal of Veterinary Medical Science
Volume	61
Issue number	6
DOIs	https://doi.org/10.1292/jvms.61.683
Publication status	Published - 1999 Jun
Externally published	Yes

Keywords

Marek's disease virus serotype 2
Transcript
UL52

ASJC Scopus subject areas

veterinary(all)

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10.1292/jvms.61.683

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title = "Identification and sequence analysis of the Marek's disease virus serotype 2 gene homologous to the herpes simplex virus type 1 UL52 protein",

abstract = "The gene of Marek's disease virus serotype 2 (MDV2) homologous to the UL52 gene of herpes simplex virus type 1 (HSV-1) was identified and characterized. The MDV2 UL52 homologous gene encodes 1,071 amino acids with a molecular weight of 118.7 kDa, which includes putative metal-binding site and overlapping region with the UL53 homologous gene. Although a putative polyadenylation signal sequence was found in the downstream of the MDV2 UL52 gene, a MDV2 UL52 DNA probe reacted only with the polycistronic 6.3 kb transcript, representing the UL52 and the downstream genes of UL53 and UL54. Transcriptional pattern of this region of MDV2 was somewhat different from corresponding regions of HSV-1 and infectious laryngotracheitis virus.",

keywords = "Marek's disease virus serotype 2, Transcript, UL52",

author = "Yoshihiro Izumiya and Jang, {Hyung Kwan} and Cai, {Jin Shun} and Yorihiro Nishimura and Kazuya Nakamura and Yoshinori Tsushima and Kentaro Kato and Takayuki Miyazawa and Chieko Kai and Takeshi Mikami",

year = "1999",

month = jun,

doi = "10.1292/jvms.61.683",

language = "English",

volume = "61",

pages = "683--687",

journal = "Journal of Veterinary Medical Science",

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publisher = "Japanese Society of Veterinary Science",

number = "6",

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TY - JOUR

T1 - Identification and sequence analysis of the Marek's disease virus serotype 2 gene homologous to the herpes simplex virus type 1 UL52 protein

AU - Izumiya, Yoshihiro

AU - Jang, Hyung Kwan

AU - Cai, Jin Shun

AU - Nishimura, Yorihiro

AU - Nakamura, Kazuya

AU - Tsushima, Yoshinori

AU - Kato, Kentaro

AU - Miyazawa, Takayuki

AU - Kai, Chieko

AU - Mikami, Takeshi

PY - 1999/6

Y1 - 1999/6

N2 - The gene of Marek's disease virus serotype 2 (MDV2) homologous to the UL52 gene of herpes simplex virus type 1 (HSV-1) was identified and characterized. The MDV2 UL52 homologous gene encodes 1,071 amino acids with a molecular weight of 118.7 kDa, which includes putative metal-binding site and overlapping region with the UL53 homologous gene. Although a putative polyadenylation signal sequence was found in the downstream of the MDV2 UL52 gene, a MDV2 UL52 DNA probe reacted only with the polycistronic 6.3 kb transcript, representing the UL52 and the downstream genes of UL53 and UL54. Transcriptional pattern of this region of MDV2 was somewhat different from corresponding regions of HSV-1 and infectious laryngotracheitis virus.

AB - The gene of Marek's disease virus serotype 2 (MDV2) homologous to the UL52 gene of herpes simplex virus type 1 (HSV-1) was identified and characterized. The MDV2 UL52 homologous gene encodes 1,071 amino acids with a molecular weight of 118.7 kDa, which includes putative metal-binding site and overlapping region with the UL53 homologous gene. Although a putative polyadenylation signal sequence was found in the downstream of the MDV2 UL52 gene, a MDV2 UL52 DNA probe reacted only with the polycistronic 6.3 kb transcript, representing the UL52 and the downstream genes of UL53 and UL54. Transcriptional pattern of this region of MDV2 was somewhat different from corresponding regions of HSV-1 and infectious laryngotracheitis virus.

KW - Marek's disease virus serotype 2

KW - Transcript

KW - UL52

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DO - 10.1292/jvms.61.683

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JO - Journal of Veterinary Medical Science

JF - Journal of Veterinary Medical Science

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ER -

Identification and sequence analysis of the Marek's disease virus serotype 2 gene homologous to the herpes simplex virus type 1 UL52 protein

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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