Identification of Senescent Cells in Peri-Implantitis and Prevention of Mini-Implant Loss Using Senolytics

Niuxin Yang, Masato Nakagawa, Aki Nishiura, Masahiro Yamada, Hidetoshi Morikuni, Yoshitomo Honda, Naoyuki Matsumoto

Research output: Contribution to journalArticlepeer-review


Peri-implantitis is a disease that causes the detachment of orthodontic mini-implants. Recently, stress-induced senescent cells have been reported to be involved in various inflammatory diseases. Senescent cell-eliminating drugs, termed “senolytics”, can improve the symptoms of such diseases. However, the relationship between peri-implantitis and senescent cells remains unclear. In this study, we evaluated the presence of senescent cells in a rat peri-implantitis model developed with a gum ring. The effect on bone resorption and implant loss was also investigated with and without senolytics (Dasatinib and Quercetin). The number of senescence markers (p19, p21, and p16) was found to increase, and implant detachment occurred in 24 days. After the administration of senolytics, the number of senescence markers decreased and implant detachment was inhibited. This study suggests that senescent cells aggravate peri-implantitis and senolytic administration latently reduces implant loss by inhibiting senescence-related mechanisms.

Original languageEnglish
Article number2507
JournalInternational journal of molecular sciences
Issue number3
Publication statusPublished - 2023 Feb


  • Dasatinib
  • mini-implant
  • orthodontics
  • peri-implantitis
  • Quersetin
  • senescence
  • senolytics

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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