IL-10 gene polymorphism, but not TGF-β1 gene polymorphisms, is associated with food allergy in a Japanese population

Eduardo Jose Campos Alberto; Naoki Shimojo; Yoichi Suzuki; Yoichi Mashimo; Takayasu Arima; Tomoko Matsuura; Yuzaburo Inoue; Akiko Yamaide; Minako Tomiita; Katsunori Fujii; Akira Hata; Yoichi Kohno

doi:10.1111/j.1399-3038.2007.00709.x

IL-10 gene polymorphism, but not TGF-β1 gene polymorphisms, is associated with food allergy in a Japanese population

Eduardo Jose Campos Alberto, Naoki Shimojo, Yoichi Suzuki, Yoichi Mashimo, Takayasu Arima, Tomoko Matsuura, Yuzaburo Inoue, Akiko Yamaide, Minako Tomiita, Katsunori Fujii, Akira Hata, Yoichi Kohno

Tohoku Medical Megabank Organization (ToMMo)

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

The regulatory IL-10 and TGF-β1 cytokine gene polymorphisms have been associated with allergic diseases in different populations, like Caucasian, Chinese and Indians. We investigated the association between the polymorphisms IL-10 A-1082G, C-819T, C-627A and TGF-β1 T+869C, G+915C, C-509T and food allergy in Japanese children. One hundred and eleven children with food allergy and 115 atopic control children without food allergy were recruited. DNA samples from these subjects were genotyped by using PCR. The odds ratio of IL-10 -1082 AA genotype was 2.5 (95% CI, 1.0-6.4) for food allergy risk when compared with atopic control subjects (p = 0.03). There were no significative differences in the frequency of TGF-β1 gene polymorphisms between both groups. Our results indicate that IL-10 A-1082G gene polymorphism is associated with food allergy susceptibility in atopic Japanese children.

Original language	English
Pages (from-to)	716-721
Number of pages	6
Journal	Pediatric Allergy and Immunology
Volume	19
Issue number	8
DOIs	https://doi.org/10.1111/j.1399-3038.2007.00709.x
Publication status	Published - 2008 Dec 1

Keywords

Food allergy
Gene
IL-10
Polymorphism
TGF-β1
Transcription factor

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Immunology and Allergy
Immunology

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10.1111/j.1399-3038.2007.00709.x

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Campos Alberto, E. J., Shimojo, N., Suzuki, Y., Mashimo, Y., Arima, T., Matsuura, T., Inoue, Y., Yamaide, A., Tomiita, M., Fujii, K., Hata, A., & Kohno, Y. (2008). IL-10 gene polymorphism, but not TGF-β1 gene polymorphisms, is associated with food allergy in a Japanese population. Pediatric Allergy and Immunology, 19(8), 716-721. https://doi.org/10.1111/j.1399-3038.2007.00709.x

Campos Alberto, EJ, Shimojo, N, Suzuki, Y, Mashimo, Y, Arima, T, Matsuura, T, Inoue, Y, Yamaide, A, Tomiita, M, Fujii, K, Hata, A & Kohno, Y 2008, 'IL-10 gene polymorphism, but not TGF-β1 gene polymorphisms, is associated with food allergy in a Japanese population', Pediatric Allergy and Immunology, vol. 19, no. 8, pp. 716-721. https://doi.org/10.1111/j.1399-3038.2007.00709.x

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doi = "10.1111/j.1399-3038.2007.00709.x",

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AU - Campos Alberto, Eduardo Jose

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AU - Suzuki, Yoichi

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AU - Arima, Takayasu

AU - Matsuura, Tomoko

AU - Inoue, Yuzaburo

AU - Yamaide, Akiko

AU - Tomiita, Minako

AU - Fujii, Katsunori

AU - Hata, Akira

AU - Kohno, Yoichi

PY - 2008/12/1

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N2 - The regulatory IL-10 and TGF-β1 cytokine gene polymorphisms have been associated with allergic diseases in different populations, like Caucasian, Chinese and Indians. We investigated the association between the polymorphisms IL-10 A-1082G, C-819T, C-627A and TGF-β1 T+869C, G+915C, C-509T and food allergy in Japanese children. One hundred and eleven children with food allergy and 115 atopic control children without food allergy were recruited. DNA samples from these subjects were genotyped by using PCR. The odds ratio of IL-10 -1082 AA genotype was 2.5 (95% CI, 1.0-6.4) for food allergy risk when compared with atopic control subjects (p = 0.03). There were no significative differences in the frequency of TGF-β1 gene polymorphisms between both groups. Our results indicate that IL-10 A-1082G gene polymorphism is associated with food allergy susceptibility in atopic Japanese children.

AB - The regulatory IL-10 and TGF-β1 cytokine gene polymorphisms have been associated with allergic diseases in different populations, like Caucasian, Chinese and Indians. We investigated the association between the polymorphisms IL-10 A-1082G, C-819T, C-627A and TGF-β1 T+869C, G+915C, C-509T and food allergy in Japanese children. One hundred and eleven children with food allergy and 115 atopic control children without food allergy were recruited. DNA samples from these subjects were genotyped by using PCR. The odds ratio of IL-10 -1082 AA genotype was 2.5 (95% CI, 1.0-6.4) for food allergy risk when compared with atopic control subjects (p = 0.03). There were no significative differences in the frequency of TGF-β1 gene polymorphisms between both groups. Our results indicate that IL-10 A-1082G gene polymorphism is associated with food allergy susceptibility in atopic Japanese children.

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KW - Transcription factor

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IL-10 gene polymorphism, but not TGF-β1 gene polymorphisms, is associated with food allergy in a Japanese population

Abstract

Keywords

ASJC Scopus subject areas

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