@article{252adfd4061f4bc4b590b2325f09b645,
title = "IL-12p40 gene expression in lung and hilar lymph nodes of MPS-resistant pigs",
abstract = "Mycoplasma pneumonia of swine (MPS) is caused by Mycoplasma hyopneumoniae (M.hp) and is a common chronic respiratory disease of pigs. Recently, a genetically selected variant of the Landrace pig (Miyagino L2) has a lower incidence of pulmonary MPS lesions. We investigated the pathological and immunological characteristics of MPS resistance in these pigs (n = 24) by comparing with the normal landrace pig (control: n = 24). The pathological MPS lung lesion score in MPS-selected landrace pigs was significantly lower than in the control. The gene expression of interleukin (IL)-12p40, which acts as a chemoattractant and a component of the bioactive cytokines IL-12 and IL-23, was significantly higher at the hilar lymph nodes, lung, and spleen in MPS-selected landrace pigs than in control landrace pigs, and these were negatively correlated with the macroscopic MPS lung lesion score. In summary, we demonstrate that resistance against MPS in Miyagino L2 pigs is associated with IL-12p40 up-regulation, in comparison with normal landrace pigs without the MPS vaccine. In addition, a comparative study of macroscopic MPS lung lesions and IL-12p40 gene expression in lung and hilar lymph nodes may lead to beneficial selection traits for the genetic selection for MPS resistance in pigs.",
keywords = "cytokine, disease resistance, histopathology, landrace pigs, Mycoplasma hyopneumoniae",
author = "Akiko Sakuma and Shizuka Sugawara and Hikaru Hidaka and Mitsuru Nakajo and Yoshihito Suda and Tomoyuki Shimazu and Rose, {Michael T.} and Megumi Urakawa and Tao Zhuang and Guoqi Zhao and Kouichi Watanabe and Tomonori Nochi and Haruki Kitazawa and Kazuo Katoh and Keiichi Suzuki and Hisashi Aso",
note = "Funding Information: This study was supported by the Program for Promotion of Basic Applied Research for Innovations in Bio‐oriented Industry to Dr. K. Suzuki, the research grant project of the Ito foundation to AS, and Japan Racing Association (No. 272) to HA. This research was also supported by a Grant‐in‐Aid for Scientific Research (A) (19H00965), and grant from the project of NARO Bio‐oriented Technology Research Advancement Institution (Research Program on development of innovation technology, No. 01002A) to HK. Funding Information: This study was supported by the Program for Promotion of Basic Applied Research for Innovations in Bio-oriented Industry to Dr. K. Suzuki, the research grant project of the Ito foundation to AS, and Japan Racing Association (No. 272) to HA. This research was also supported by a Grant-in-Aid for Scientific Research (A) (19H00965), and grant from the project of NARO Bio-oriented Technology Research Advancement Institution (Research Program on development of innovation technology, No. 01002A) to HK. Publisher Copyright: {\textcopyright} 2020 Japanese Society of Animal Science",
year = "2020",
month = jan,
day = "1",
doi = "10.1111/asj.13450",
language = "English",
volume = "91",
journal = "Animal Science Journal",
issn = "1344-3941",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "1",
}
