Image enhancement of optical images for binary system of melanocytes and keratinocytes

S. Takanezawa, A. Baba, Y. Sako, Y. Ozaki, A. Date, K. Toyama, S. Morita

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Automatic determination of the cell shapes of large numbers of melanocytes based on optical images of human skin models have been largely unsuccessful (the complexities introduced by dendrites and the melanin pigmentation over the keratinocytes to give unclear outlines). Here, we present an image enhancement procedure for enhancing the contrast of images with removing the non-uniformity of background. The brightness is normalized also for the non-uniform population density of melanocytes.

Original languageEnglish
Title of host publicationNano-Bio Sensing, Imaging, and Spectroscopy
Publication statusPublished - 2013
EventSPIE Nano-Bio Sensing, Imaging, and Spectroscopy - Jeju, Korea, Republic of
Duration: 2013 Feb 202013 Feb 23

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X


ConferenceSPIE Nano-Bio Sensing, Imaging, and Spectroscopy
Country/TerritoryKorea, Republic of


  • Melanocytes
  • Otsu's method
  • cell shape
  • local histogram equalization
  • microscope
  • outlines
  • skin model


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