Abstract
Boron neutron capture therapy (BNCT) is a cancer-selective radiotherapy to treat malignant tumors using a nuclear reaction of boron isotopes in tumor-localizing drug molecules. To evaluate the efficacy of boron drugs for BNCT, it is crucial to measure the distribution of boron drugs in cells. Here, we present the direct imaging of cellular uptake of boron cluster compound by stimulated Raman scattering microscopy. We demonstrate quantitative analysis of spatial distributions of disodium mercaptoundecahydrododecaborate (BSH)-cholesterol in HeLa cells.
| Original language | English |
|---|---|
| Article number | 112004 |
| Journal | Applied Physics Express |
| Volume | 12 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2019 Nov 1 |
| Externally published | Yes |
ASJC Scopus subject areas
- Engineering(all)
- Physics and Astronomy(all)
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In: Applied Physics Express, Vol. 12, No. 11, 112004, 01.11.2019.
Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Imaging of cellular uptake of boron cluster compound by stimulated Raman scattering microscopy
AU - Asai, Takuya
AU - Liu, Hanqin
AU - Ozeki, Yasuyuki
AU - Sato, Shinichi
AU - Hayashi, Tomohiro
AU - Nakamura, Hiroyuki
N1 - Funding Information: Takuya Asai Hanqin Liu Yasuyuki Ozeki Shinichi Sato Tomohiro Hayashi Hiroyuki Nakamura Takuya Asai Hanqin Liu Yasuyuki Ozeki Shinichi Sato Tomohiro Hayashi Hiroyuki Nakamura Department of Electrical Engineering and Information Systems, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsuta-Cho, Midori-ku, Yokohama 226-8503, Japan School of Materials and Chemical Technology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8502, Japan JST-PRESTO, 4-1-8 Hon-cho, Kawaguchi, Saitama 332-0012, Japan Takuya Asai, Hanqin Liu, Yasuyuki Ozeki, Shinichi Sato, Tomohiro Hayashi and Hiroyuki Nakamura 2019-11-01 2019-10-16 15:06:49 cgi/release: Article released bin/incoming: New from .zip Ministry of Education, Culture, Sports, Science and Technology https://doi.org/10.13039/501100001700 15KK0184 17H02202 17K20095 18H045420 18K18847 Core Research for Evolutional Science and Technology https://doi.org/10.13039/501100003382 JPMJCR1872 yes Boron neutron capture therapy (BNCT) is a cancer-selective radiotherapy to treat malignant tumors using a nuclear reaction of boron isotopes in tumor-localizing drug molecules. To evaluate the efficacy of boron drugs for BNCT, it is crucial to measure the distribution of boron drugs in cells. Here, we present the direct imaging of cellular uptake of boron cluster compound by stimulated Raman scattering microscopy. We demonstrate quantitative analysis of spatial distributions of disodium mercaptoundecahydrododecaborate (BSH)-cholesterol in HeLa cells. � 2019 The Japan Society of Applied Physics [1] Barth R. F., Coderre J. A., Vicente M. G. H. and Blue T. E. 2005 Clin. Cancer Res. 11 3987 10.1158/1078-0432.CCR-05-0035 Barth R. F., Coderre J. A., Vicente M. G. H. and Blue T. E. Clin. Cancer Res. 1078-0432 11 2005 3987 [2] Nakamura H. 2013 Future Med. Chem. 5 715 10.4155/fmc.13.48 Nakamura H. Future Med. Chem. 5 2013 715 [3] Moss R. L. 2014 Appl. Radiat. Isot. 88 2 10.1016/j.apradiso.2013.11.109 Moss R. L. Appl. Radiat. Isot. 0883-2889 88 2014 2 [4] Aihara T., Morita N., Kamatani N., Kumada H., Ono K., Hiratsuka J. and Harada T. 2014 Appl. Radiat. 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PY - 2019/11/1
Y1 - 2019/11/1
N2 - Boron neutron capture therapy (BNCT) is a cancer-selective radiotherapy to treat malignant tumors using a nuclear reaction of boron isotopes in tumor-localizing drug molecules. To evaluate the efficacy of boron drugs for BNCT, it is crucial to measure the distribution of boron drugs in cells. Here, we present the direct imaging of cellular uptake of boron cluster compound by stimulated Raman scattering microscopy. We demonstrate quantitative analysis of spatial distributions of disodium mercaptoundecahydrododecaborate (BSH)-cholesterol in HeLa cells.
AB - Boron neutron capture therapy (BNCT) is a cancer-selective radiotherapy to treat malignant tumors using a nuclear reaction of boron isotopes in tumor-localizing drug molecules. To evaluate the efficacy of boron drugs for BNCT, it is crucial to measure the distribution of boron drugs in cells. Here, we present the direct imaging of cellular uptake of boron cluster compound by stimulated Raman scattering microscopy. We demonstrate quantitative analysis of spatial distributions of disodium mercaptoundecahydrododecaborate (BSH)-cholesterol in HeLa cells.
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UR - http://www.scopus.com/inward/citedby.url?scp=85075982520&partnerID=8YFLogxK
U2 - 10.7567/1882-0786/ab4a5d
DO - 10.7567/1882-0786/ab4a5d
M3 - Article
AN - SCOPUS:85075982520
SN - 1882-0778
VL - 12
JO - Applied Physics Express
JF - Applied Physics Express
IS - 11
M1 - 112004
ER -