Immunocytochemical evaluation of large cell neuroendocrine carcinoma of the lung

Chiaki Endo, Masako Honda, Akira Sakurada, Masami Sato, Yasuki Saito, Takashi Kondo

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Objective: To examine whether immunocytochemistry can distinguish pulmonary large cell neuroendocrine carcinoma (LCNEC) among non-small cell lung cancers (NSCLCs). Study Design: Tumor touch imprint cytologic specimens of 109 lung cancers were studied. Immunocytochemistry was done using a total of 8 primary antibodies: chromogranin A, synaptophysin, neural cell adhesion molecule, neuron specific enolase, CK34βE12, thyroid transcription factor-1, cytokeratin 18 and E-cadherin. Results: If 2 or 3 antibodies of chromogranin A, synaptophysin and neural cell adhesion molecule were stained positive and CK34βE12 was not stained, pulmonary LCNEC can be selected accurately among other NSCLCs with 100% sensitivity and 100% specificity. Conclusion: This study reveals that immunocytochemistry can help distinguish LCNEC of the lung from other NSCLCs.

Original languageEnglish
Pages (from-to)36-40
Number of pages5
JournalActa Cytologica
Issue number1
Publication statusPublished - 2009


  • Immunocytochemistry
  • Large cell neuroendocrine carcinoma
  • Neuroendocrine tumor
  • Non-small cell lung cancer

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology


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