Immunocytochemical evaluation of large cell neuroendocrine carcinoma of the lung

Chiaki Endo; Masako Honda; Akira Sakurada; Masami Sato; Yasuki Saito; Takashi Kondo

doi:10.1159/000325083

Immunocytochemical evaluation of large cell neuroendocrine carcinoma of the lung

Chiaki Endo, Masako Honda, Akira Sakurada, Masami Sato, Yasuki Saito, Takashi Kondo

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Objective: To examine whether immunocytochemistry can distinguish pulmonary large cell neuroendocrine carcinoma (LCNEC) among non-small cell lung cancers (NSCLCs). Study Design: Tumor touch imprint cytologic specimens of 109 lung cancers were studied. Immunocytochemistry was done using a total of 8 primary antibodies: chromogranin A, synaptophysin, neural cell adhesion molecule, neuron specific enolase, CK34βE12, thyroid transcription factor-1, cytokeratin 18 and E-cadherin. Results: If 2 or 3 antibodies of chromogranin A, synaptophysin and neural cell adhesion molecule were stained positive and CK34βE12 was not stained, pulmonary LCNEC can be selected accurately among other NSCLCs with 100% sensitivity and 100% specificity. Conclusion: This study reveals that immunocytochemistry can help distinguish LCNEC of the lung from other NSCLCs.

Original language	English
Pages (from-to)	36-40
Number of pages	5
Journal	Acta Cytologica
Volume	53
Issue number	1
DOIs	https://doi.org/10.1159/000325083
Publication status	Published - 2009

Keywords

Immunocytochemistry
Large cell neuroendocrine carcinoma
Neuroendocrine tumor
Non-small cell lung cancer

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000325083

Cite this

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title = "Immunocytochemical evaluation of large cell neuroendocrine carcinoma of the lung",

abstract = "Objective: To examine whether immunocytochemistry can distinguish pulmonary large cell neuroendocrine carcinoma (LCNEC) among non-small cell lung cancers (NSCLCs). Study Design: Tumor touch imprint cytologic specimens of 109 lung cancers were studied. Immunocytochemistry was done using a total of 8 primary antibodies: chromogranin A, synaptophysin, neural cell adhesion molecule, neuron specific enolase, CK34βE12, thyroid transcription factor-1, cytokeratin 18 and E-cadherin. Results: If 2 or 3 antibodies of chromogranin A, synaptophysin and neural cell adhesion molecule were stained positive and CK34βE12 was not stained, pulmonary LCNEC can be selected accurately among other NSCLCs with 100% sensitivity and 100% specificity. Conclusion: This study reveals that immunocytochemistry can help distinguish LCNEC of the lung from other NSCLCs.",

keywords = "Immunocytochemistry, Large cell neuroendocrine carcinoma, Neuroendocrine tumor, Non-small cell lung cancer",

author = "Chiaki Endo and Masako Honda and Akira Sakurada and Masami Sato and Yasuki Saito and Takashi Kondo",

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doi = "10.1159/000325083",

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T1 - Immunocytochemical evaluation of large cell neuroendocrine carcinoma of the lung

AU - Endo, Chiaki

AU - Honda, Masako

AU - Sakurada, Akira

AU - Sato, Masami

AU - Saito, Yasuki

AU - Kondo, Takashi

PY - 2009

Y1 - 2009

N2 - Objective: To examine whether immunocytochemistry can distinguish pulmonary large cell neuroendocrine carcinoma (LCNEC) among non-small cell lung cancers (NSCLCs). Study Design: Tumor touch imprint cytologic specimens of 109 lung cancers were studied. Immunocytochemistry was done using a total of 8 primary antibodies: chromogranin A, synaptophysin, neural cell adhesion molecule, neuron specific enolase, CK34βE12, thyroid transcription factor-1, cytokeratin 18 and E-cadherin. Results: If 2 or 3 antibodies of chromogranin A, synaptophysin and neural cell adhesion molecule were stained positive and CK34βE12 was not stained, pulmonary LCNEC can be selected accurately among other NSCLCs with 100% sensitivity and 100% specificity. Conclusion: This study reveals that immunocytochemistry can help distinguish LCNEC of the lung from other NSCLCs.

AB - Objective: To examine whether immunocytochemistry can distinguish pulmonary large cell neuroendocrine carcinoma (LCNEC) among non-small cell lung cancers (NSCLCs). Study Design: Tumor touch imprint cytologic specimens of 109 lung cancers were studied. Immunocytochemistry was done using a total of 8 primary antibodies: chromogranin A, synaptophysin, neural cell adhesion molecule, neuron specific enolase, CK34βE12, thyroid transcription factor-1, cytokeratin 18 and E-cadherin. Results: If 2 or 3 antibodies of chromogranin A, synaptophysin and neural cell adhesion molecule were stained positive and CK34βE12 was not stained, pulmonary LCNEC can be selected accurately among other NSCLCs with 100% sensitivity and 100% specificity. Conclusion: This study reveals that immunocytochemistry can help distinguish LCNEC of the lung from other NSCLCs.

KW - Immunocytochemistry

KW - Large cell neuroendocrine carcinoma

KW - Neuroendocrine tumor

KW - Non-small cell lung cancer

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Immunocytochemical evaluation of large cell neuroendocrine carcinoma of the lung

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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