Immunogenic properties of Landrace pigs selected for resistance to mycoplasma pneumonia of swine

Liushiqi Borjigin; Tomoyuki Shimazu; Yuki Katayama; Meihua Li; Takumi Satoh; Kouichi Watanabe; Haruki Kitazawa; Sang Gun Roh; Hisashi Aso; Kazuo Katoh; Takafumi Uchida; Yoshihito Suda; Akiko Sakuma; Mituru Nakajo; Keiichi Suzuki

doi:10.1111/asj.12440

Immunogenic properties of Landrace pigs selected for resistance to mycoplasma pneumonia of swine

Liushiqi Borjigin, Tomoyuki Shimazu, Yuki Katayama, Meihua Li, Takumi Satoh, Kouichi Watanabe, Haruki Kitazawa, Sang Gun Roh, Hisashi Aso, Kazuo Katoh, Takafumi Uchida, Yoshihito Suda, Akiko Sakuma, Mituru Nakajo, Keiichi Suzuki

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Mycoplasma pneumonia of swine (MPS) lung lesions and immunogenic properties were compared between a Landrace line that was genetically selected for reduced incidence of pulmonary MPS lesions, and a non-selected Landrace line. The MPS-selected Landrace line showed significantly lower degrees of pulmonary MPS lesions compared with the non-selected Landrace line. When changes in immunity before and after vaccination were compared, the percentage of B cells in the peripheral blood of the MPS-selected Landrace line was significantly lower than that of the non-selected line. Furthermore, the concentration of growth hormone and the mitogen activity of peripheral blood mononuclear cells in the MPS-selected Landrace line showed significantly (P<0.05) lower increases after vaccination than the non-selected line. Conversely, the concentration of peripheral blood interferon (IFN)-γ and salivary immunoglobulin A (IgA) after Mycoplasma hyopneumoniae vaccination was significantly higher in the MPS-selected Landrace line than in the non-selected line. Gene expression of toll-like receptor (TLR)2 and TLR4 was significantly higher in the MPS-selected Landrace line in immune tissues, with the exception of the hilar lymph nodes. The present results suggest that peripheral blood IFN-γ, salivary IgA TLR2, and TLR4 are important immunological factors influencing the development of MPS lesions.

Original language	English
Pages (from-to)	321-329
Number of pages	9
Journal	Animal Science Journal
Volume	87
Issue number	3
DOIs	https://doi.org/10.1111/asj.12440
Publication status	Published - 2016 Mar 1

Keywords

Disease resistance
Immunogenic properties
Mycoplasma pneumonia lesions
Pig

ASJC Scopus subject areas

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/asj.12440

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title = "Immunogenic properties of Landrace pigs selected for resistance to mycoplasma pneumonia of swine",

abstract = "Mycoplasma pneumonia of swine (MPS) lung lesions and immunogenic properties were compared between a Landrace line that was genetically selected for reduced incidence of pulmonary MPS lesions, and a non-selected Landrace line. The MPS-selected Landrace line showed significantly lower degrees of pulmonary MPS lesions compared with the non-selected Landrace line. When changes in immunity before and after vaccination were compared, the percentage of B cells in the peripheral blood of the MPS-selected Landrace line was significantly lower than that of the non-selected line. Furthermore, the concentration of growth hormone and the mitogen activity of peripheral blood mononuclear cells in the MPS-selected Landrace line showed significantly (P<0.05) lower increases after vaccination than the non-selected line. Conversely, the concentration of peripheral blood interferon (IFN)-γ and salivary immunoglobulin A (IgA) after Mycoplasma hyopneumoniae vaccination was significantly higher in the MPS-selected Landrace line than in the non-selected line. Gene expression of toll-like receptor (TLR)2 and TLR4 was significantly higher in the MPS-selected Landrace line in immune tissues, with the exception of the hilar lymph nodes. The present results suggest that peripheral blood IFN-γ, salivary IgA TLR2, and TLR4 are important immunological factors influencing the development of MPS lesions.",

keywords = "Disease resistance, Immunogenic properties, Mycoplasma pneumonia lesions, Pig",

author = "Liushiqi Borjigin and Tomoyuki Shimazu and Yuki Katayama and Meihua Li and Takumi Satoh and Kouichi Watanabe and Haruki Kitazawa and Roh, {Sang Gun} and Hisashi Aso and Kazuo Katoh and Takafumi Uchida and Yoshihito Suda and Akiko Sakuma and Mituru Nakajo and Keiichi Suzuki",

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doi = "10.1111/asj.12440",

language = "English",

volume = "87",

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T1 - Immunogenic properties of Landrace pigs selected for resistance to mycoplasma pneumonia of swine

AU - Borjigin, Liushiqi

AU - Shimazu, Tomoyuki

AU - Katayama, Yuki

AU - Li, Meihua

AU - Satoh, Takumi

AU - Watanabe, Kouichi

AU - Kitazawa, Haruki

AU - Roh, Sang Gun

AU - Aso, Hisashi

AU - Katoh, Kazuo

AU - Uchida, Takafumi

AU - Suda, Yoshihito

AU - Sakuma, Akiko

AU - Nakajo, Mituru

AU - Suzuki, Keiichi

PY - 2016/3/1

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N2 - Mycoplasma pneumonia of swine (MPS) lung lesions and immunogenic properties were compared between a Landrace line that was genetically selected for reduced incidence of pulmonary MPS lesions, and a non-selected Landrace line. The MPS-selected Landrace line showed significantly lower degrees of pulmonary MPS lesions compared with the non-selected Landrace line. When changes in immunity before and after vaccination were compared, the percentage of B cells in the peripheral blood of the MPS-selected Landrace line was significantly lower than that of the non-selected line. Furthermore, the concentration of growth hormone and the mitogen activity of peripheral blood mononuclear cells in the MPS-selected Landrace line showed significantly (P<0.05) lower increases after vaccination than the non-selected line. Conversely, the concentration of peripheral blood interferon (IFN)-γ and salivary immunoglobulin A (IgA) after Mycoplasma hyopneumoniae vaccination was significantly higher in the MPS-selected Landrace line than in the non-selected line. Gene expression of toll-like receptor (TLR)2 and TLR4 was significantly higher in the MPS-selected Landrace line in immune tissues, with the exception of the hilar lymph nodes. The present results suggest that peripheral blood IFN-γ, salivary IgA TLR2, and TLR4 are important immunological factors influencing the development of MPS lesions.

AB - Mycoplasma pneumonia of swine (MPS) lung lesions and immunogenic properties were compared between a Landrace line that was genetically selected for reduced incidence of pulmonary MPS lesions, and a non-selected Landrace line. The MPS-selected Landrace line showed significantly lower degrees of pulmonary MPS lesions compared with the non-selected Landrace line. When changes in immunity before and after vaccination were compared, the percentage of B cells in the peripheral blood of the MPS-selected Landrace line was significantly lower than that of the non-selected line. Furthermore, the concentration of growth hormone and the mitogen activity of peripheral blood mononuclear cells in the MPS-selected Landrace line showed significantly (P<0.05) lower increases after vaccination than the non-selected line. Conversely, the concentration of peripheral blood interferon (IFN)-γ and salivary immunoglobulin A (IgA) after Mycoplasma hyopneumoniae vaccination was significantly higher in the MPS-selected Landrace line than in the non-selected line. Gene expression of toll-like receptor (TLR)2 and TLR4 was significantly higher in the MPS-selected Landrace line in immune tissues, with the exception of the hilar lymph nodes. The present results suggest that peripheral blood IFN-γ, salivary IgA TLR2, and TLR4 are important immunological factors influencing the development of MPS lesions.

KW - Disease resistance

KW - Immunogenic properties

KW - Mycoplasma pneumonia lesions

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Immunogenic properties of Landrace pigs selected for resistance to mycoplasma pneumonia of swine

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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