Immunohistochemical study for basic fibroblast growth factor and fibroblast growth factor receptor I in pituitary adenomas

Hiroshi Suzui; Jun A. Takahashi; Manabu Fukumoto; Nobuo Hashimoto; Nobuyuki Itoh; Masakazu Hatanaka; Haruhiko Kikuchi

doi:10.1016/0304-3940(94)90637-8

Immunohistochemical study for basic fibroblast growth factor and fibroblast growth factor receptor I in pituitary adenomas

Hiroshi Suzui, Jun A. Takahashi, Manabu Fukumoto, Nobuo Hashimoto, Nobuyuki Itoh, Masakazu Hatanaka, Haruhiko Kikuchi

Division of Cancer Science

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Immunohistochemistry and RT-PCR of basic fibroblast growth factor (bFGF) and one of its receptors (FGFR-I) were performed in pituitary adenomas. Sixty percent of pituitary adenomas showed strong or moderate immunoreactivity to bFGF. The immunoreactivity for FGFR-I in tumor tissues showed positive correlation to that for bFGF (χ² = 6.176, P = 0.0456). Basic FGF-positive cells consisted of pituitary adenoma cells as well as folliculostellate cells and, their distribution was heterogeneous. Expressions of bFGF and FGFR-I were not related to cell proliferation of pituitary adenomas or hormones produced, suggesting that bFGF plays some role other than progression of pituitary adenomas.

Original language	English
Pages (from-to)	192-196
Number of pages	5
Journal	Neuroscience Letters
Volume	171
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(94)90637-8
Publication status	Published - 1994 Apr 25

Keywords

Basic fibroblast growth factor
Fibroblast growth factor receptor I
Immunohistochemistry
Pituitary adenoma
Proliferating cellular nucleolar antigen
RT-PCR
S-100

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(94)90637-8

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title = "Immunohistochemical study for basic fibroblast growth factor and fibroblast growth factor receptor I in pituitary adenomas",

abstract = "Immunohistochemistry and RT-PCR of basic fibroblast growth factor (bFGF) and one of its receptors (FGFR-I) were performed in pituitary adenomas. Sixty percent of pituitary adenomas showed strong or moderate immunoreactivity to bFGF. The immunoreactivity for FGFR-I in tumor tissues showed positive correlation to that for bFGF (χ2 = 6.176, P = 0.0456). Basic FGF-positive cells consisted of pituitary adenoma cells as well as folliculostellate cells and, their distribution was heterogeneous. Expressions of bFGF and FGFR-I were not related to cell proliferation of pituitary adenomas or hormones produced, suggesting that bFGF plays some role other than progression of pituitary adenomas.",

keywords = "Basic fibroblast growth factor, Fibroblast growth factor receptor I, Immunohistochemistry, Pituitary adenoma, Proliferating cellular nucleolar antigen, RT-PCR, S-100",

author = "Hiroshi Suzui and Takahashi, {Jun A.} and Manabu Fukumoto and Nobuo Hashimoto and Nobuyuki Itoh and Masakazu Hatanaka and Haruhiko Kikuchi",

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doi = "10.1016/0304-3940(94)90637-8",

language = "English",

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T1 - Immunohistochemical study for basic fibroblast growth factor and fibroblast growth factor receptor I in pituitary adenomas

AU - Suzui, Hiroshi

AU - Takahashi, Jun A.

AU - Fukumoto, Manabu

AU - Hashimoto, Nobuo

AU - Itoh, Nobuyuki

AU - Hatanaka, Masakazu

AU - Kikuchi, Haruhiko

PY - 1994/4/25

Y1 - 1994/4/25

N2 - Immunohistochemistry and RT-PCR of basic fibroblast growth factor (bFGF) and one of its receptors (FGFR-I) were performed in pituitary adenomas. Sixty percent of pituitary adenomas showed strong or moderate immunoreactivity to bFGF. The immunoreactivity for FGFR-I in tumor tissues showed positive correlation to that for bFGF (χ2 = 6.176, P = 0.0456). Basic FGF-positive cells consisted of pituitary adenoma cells as well as folliculostellate cells and, their distribution was heterogeneous. Expressions of bFGF and FGFR-I were not related to cell proliferation of pituitary adenomas or hormones produced, suggesting that bFGF plays some role other than progression of pituitary adenomas.

AB - Immunohistochemistry and RT-PCR of basic fibroblast growth factor (bFGF) and one of its receptors (FGFR-I) were performed in pituitary adenomas. Sixty percent of pituitary adenomas showed strong or moderate immunoreactivity to bFGF. The immunoreactivity for FGFR-I in tumor tissues showed positive correlation to that for bFGF (χ2 = 6.176, P = 0.0456). Basic FGF-positive cells consisted of pituitary adenoma cells as well as folliculostellate cells and, their distribution was heterogeneous. Expressions of bFGF and FGFR-I were not related to cell proliferation of pituitary adenomas or hormones produced, suggesting that bFGF plays some role other than progression of pituitary adenomas.

KW - Basic fibroblast growth factor

KW - Fibroblast growth factor receptor I

KW - Immunohistochemistry

KW - Pituitary adenoma

KW - Proliferating cellular nucleolar antigen

KW - RT-PCR

KW - S-100

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JO - Neuroscience Letters

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ER -

Immunohistochemical study for basic fibroblast growth factor and fibroblast growth factor receptor I in pituitary adenomas

Abstract

Keywords

ASJC Scopus subject areas

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