Immunological mechanisms of graft versus tumor effect

Shoji Ine, Minami Yamada, Koichi Miyamura, Takeshi Sasaki

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


Lesson from hematopoietic stem cell transplantation demonstrated that donor immuno-surveillance system can eradicate tumor cells. This is so-call graft versus tumor(GVT) effect. Antigen presenting cells show peptide from minor antigen rather leukemic specific antigen in the context of major histocompatibility complex. The effector cells composed of CD8 T lymphocyte, CD4 T lymphocyte, natural killer cell and natural killer T cell. Death signal was transmitted from effector cells via granzyme/perforin system and FasL/Fas system, and recently TRAIL system seems most important for GVT effect.

Original languageEnglish
Pages (from-to)1495-1502
Number of pages8
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number9
Publication statusPublished - 2003 Sept

ASJC Scopus subject areas

  • Medicine(all)


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