Abstract
Lesson from hematopoietic stem cell transplantation demonstrated that donor immuno-surveillance system can eradicate tumor cells. This is so-call graft versus tumor(GVT) effect. Antigen presenting cells show peptide from minor antigen rather leukemic specific antigen in the context of major histocompatibility complex. The effector cells composed of CD8 T lymphocyte, CD4 T lymphocyte, natural killer cell and natural killer T cell. Death signal was transmitted from effector cells via granzyme/perforin system and FasL/Fas system, and recently TRAIL system seems most important for GVT effect.
| Original language | English |
|---|---|
| Pages (from-to) | 1495-1502 |
| Number of pages | 8 |
| Journal | Nippon rinsho. Japanese journal of clinical medicine |
| Volume | 61 |
| Issue number | 9 |
| Publication status | Published - 2003 Sept |
ASJC Scopus subject areas
- Medicine(all)