TY - JOUR
T1 - Impact of Donor Age on Outcome of Intestinal Transplantation in Japan
AU - Ueno, T.
AU - Wada, M.
AU - Hoshino, K.
AU - Matsuura, T.
AU - Okajima, H.
AU - Okuyama, H.
N1 - Funding Information:
Data were analyzed using JMP version 11 (SAS, Inc, Cary, NC). Patient and graft survival estimates were obtained using the Kaplan-Meier method. For survival analysis, failure was defined as occurring on the date of graft removal or death. Wilcoxon's test was used for Kaplan-Meier survival curve analysis. P < .05 was considered statistically significant. Our study was approved by the institutional review board of Osaka University Hospital and was supported by the Japan Agency for Medical Research and Development .
Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/11
Y1 - 2018/11
N2 - Background: Donor age for intestinal transplantation (ITx) is somewhat younger than that for other solid organs. Clear criteria for adequate donors have not been established. There is a donor scarcity for ITx in Japan due to the shortage of young donors. Methods: We reviewed outcomes associated with ITx in Japan based on donor age for cadaveric and living donation. Results: Standardized report forms were sent to all known ITx programs, asking for information on ITxs performed between 1996 and 2016. All programs responded. Patient and graft survival estimates were obtained using the Kaplan-Meier method. Five institutions provided data on 27 grafts in 24 patients. There were 14 cadaveric and 13 living donor transplants. Median donor age for ITxs was 40 (range, 17–60) years. Graft survival at 5 years was 66% for patients >40 years old (n = 18) and 47% for those <40 years old (n = 9), not a statistically significant difference (P =.49). Graft survival at 5 years was 60% in those >50 years old (n = 5) and 57% for those <50 years old (n = 22), again not a significant difference (P =.27). Conclusion: There is no difference in survival between for those with donor age <40 vs >40 years. Donor age for ITx can be extended from >40 to up to 50 years, which may help to mitigate the donor shortage. It will be necessary to clarify the donor criteria for ITx through accumulation of further data on ITx.
AB - Background: Donor age for intestinal transplantation (ITx) is somewhat younger than that for other solid organs. Clear criteria for adequate donors have not been established. There is a donor scarcity for ITx in Japan due to the shortage of young donors. Methods: We reviewed outcomes associated with ITx in Japan based on donor age for cadaveric and living donation. Results: Standardized report forms were sent to all known ITx programs, asking for information on ITxs performed between 1996 and 2016. All programs responded. Patient and graft survival estimates were obtained using the Kaplan-Meier method. Five institutions provided data on 27 grafts in 24 patients. There were 14 cadaveric and 13 living donor transplants. Median donor age for ITxs was 40 (range, 17–60) years. Graft survival at 5 years was 66% for patients >40 years old (n = 18) and 47% for those <40 years old (n = 9), not a statistically significant difference (P =.49). Graft survival at 5 years was 60% in those >50 years old (n = 5) and 57% for those <50 years old (n = 22), again not a significant difference (P =.27). Conclusion: There is no difference in survival between for those with donor age <40 vs >40 years. Donor age for ITx can be extended from >40 to up to 50 years, which may help to mitigate the donor shortage. It will be necessary to clarify the donor criteria for ITx through accumulation of further data on ITx.
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U2 - 10.1016/j.transproceed.2018.04.021
DO - 10.1016/j.transproceed.2018.04.021
M3 - Article
C2 - 30401396
AN - SCOPUS:85055861268
SN - 0041-1345
VL - 50
SP - 2775
EP - 2778
JO - Transplantation Proceedings
JF - Transplantation Proceedings
IS - 9
ER -