Impact of heart rate fragmentation on the assessment of heart rate variability

Junichiro Hayano, Masaya Kisohara, Norihiro Ueda, Emi Yuda

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Heart rate fragmentation (HRF) is a type of sinoatrial instability characterized by frequent (often every beat) appearance of inflection in the R-R interval time series, despite the electrocardiograms appearing to be sinus rhythm. Because the assessment of parasympathetic function by heart rate variability (HRV) analysis depends on the assumption that the high-frequency component (HF, 0.15-0.4 Hz) of HRV is mediated solely by the cardiac parasympathetic nerve, HRF that is measured as a part of HF power confounds the parasympathetic functional assessment by HRV. In this study, we analyzed HRF in a 24-h electrocardiogram big data and investigated the changes in HRF with age and sex and its influence on the assessment of HRV. We observed that HRF is often observed during childhoods (0-20 year) and increased after 75 year, but it has a large impact on individual differences in HF power at ages 60-90.

Original languageEnglish
Article number3314
JournalApplied Sciences (Switzerland)
Issue number9
Publication statusPublished - 2020 May 1


  • Autonomic nervous function
  • Bio-signal processing
  • Electrocardiogram
  • Heart rate
  • Heart rate fragmentation
  • Heart rate variability


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