TY - JOUR
T1 - Impact of human adenovirus serotype 7 in hospitalized children with severe fatal pneumonia in the Philippines
AU - Yamamoto, Dai
AU - Okamoto, Michiko
AU - Lupisan, Socorro
AU - Suzuki, Akira
AU - Saito, Mariko
AU - Tamaki, Raita
AU - Tandoc, Amado
AU - Mercado, Edelwisa
AU - Sombrero, Lydia
AU - Olveda, Remigio
AU - Oshitani, Hitoshi
PY - 2014
Y1 - 2014
N2 - Human adenovirus (HAdV) serotype 7 is an important etiological agent of severe childhood pneumonia. The aim of this study was to define the role of HAdV7 and to describe its clinical and molecular epidemiological characteristics in the Philippines in 2011. HAdVs were detected by viral culture, and a partial region of hexon gene was sequenced. A total of 700 patients were enrolled, of which 22 (3.1%) died. Nine (1.3%) HAdV cases were confirmed, of which 7 were positive for HAdV7, 1 for HAdV3, and 1 for HAdV5. Among the 9 HAdV-positive cases, 4 (44%) with HAdV7 died. Molecular analysis revealed that all HAdV7 isolates were closely related to genome type h strains. This study demonstrated the significance of HAdV7 as an etiological agent of severe pediatric pneumonia with a high fatality rate. Hence, continuous monitoring is required to define the clinical and public health significance of HAdV7 infection.
AB - Human adenovirus (HAdV) serotype 7 is an important etiological agent of severe childhood pneumonia. The aim of this study was to define the role of HAdV7 and to describe its clinical and molecular epidemiological characteristics in the Philippines in 2011. HAdVs were detected by viral culture, and a partial region of hexon gene was sequenced. A total of 700 patients were enrolled, of which 22 (3.1%) died. Nine (1.3%) HAdV cases were confirmed, of which 7 were positive for HAdV7, 1 for HAdV3, and 1 for HAdV5. Among the 9 HAdV-positive cases, 4 (44%) with HAdV7 died. Molecular analysis revealed that all HAdV7 isolates were closely related to genome type h strains. This study demonstrated the significance of HAdV7 as an etiological agent of severe pediatric pneumonia with a high fatality rate. Hence, continuous monitoring is required to define the clinical and public health significance of HAdV7 infection.
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U2 - 10.7883/yoken.67.105
DO - 10.7883/yoken.67.105
M3 - Article
C2 - 24647252
AN - SCOPUS:84897846920
SN - 1344-6304
VL - 67
SP - 105
EP - 110
JO - Japanese Journal of Infectious Diseases
JF - Japanese Journal of Infectious Diseases
IS - 2
ER -
