Abstract
Pancreatic cancer is characterized by constitutive activation of the mitogen-activated protein kinase (MAPK) pathway. Mutations of KRAS or BRAF and epigenetic abrogation of DUSP6 contribute synergistically to the constitutive activation of MAPK. Active MAPK induces the expression of a variety of genes that are thought to play roles in malignant phenotypes of pancreatic cancer. By blocking the functions of such induced genes, it is possible to attenuate the malignant phenotypes. The development of drugs targeting genes downstream of MAPK may provide a novel therapeutic option for pancreatic cancer.
| Original language | English |
|---|---|
| Article number | 23 |
| Journal | Frontiers in Oncology |
| Volume | 5 |
| Issue number | FEB |
| DOIs | |
| Publication status | Published - 2015 |
| Externally published | Yes |
Keywords
- BRAF
- DUSP6
- ERK
- KRAS
- MKP-3
- Mitogen-activated protein kinase
- Pancreatic cancer
- microRNA
ASJC Scopus subject areas
- Oncology
- Cancer Research
