Impaired neurogenesis in the growth-retarded mouse is reversed by T 3 treatment

Katsuya Uchida, Masako Yonezawa, Souichiro Nakamura, Tetsuya Kobayashi, Takeo Machida

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


Triiodothyronine (T3) regulates neuronal development, and T 3 deficiency impairs the formation of the central nervous system during childhood. Here, we used the hypothyroidal growth-retarded (grt) mouse to investigate whether the generation of new neurons is affected by T3 deficiency. Cell proliferation in the hippocampus, as measured by 5-bromo-2′-deoxyuridine (BrdU) incorporation, was markedly decreased in the grt mouse while the number of BrdU-positive cells in T3-treated grt mice was equivalent to that of wild type mice. The cellular differentiation rate did not differ among the experimental groups. These results suggest that T3 plays an important role during neurogenesis.

Original languageEnglish
Pages (from-to)103-106
Number of pages4
Issue number2
Publication statusPublished - 2005 Feb 8


  • Cell proliferation
  • Hippocampus
  • Hypothyroid
  • Neurogenesis
  • Thyroid hormone


Dive into the research topics of 'Impaired neurogenesis in the growth-retarded mouse is reversed by T 3 treatment'. Together they form a unique fingerprint.

Cite this