Impairment of pachytene spermatogenesis in Dmrt7 deficient mice, possibly causing meiotic arrest

Shiori Date, Osamu Nozawa, Hiroaki Inoue, Shizu Hidema, Katsuhiko Nishimori

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)


    Although Dmrt7 has been reported to be essential for male spermatogenesis, the molecular mechanism underlying pachytene spermatogenesis by Dmrt7 is not known. In the present study, by detailed analysis of Dmrt7 protein distribution in spermatocytes in the first wave of spermatogenesis, we clarified the profile of Dmrt7 expression and localization in pachytene spermatogenesis. Dmrt7-deficient spermatocytes were arrested in the pachytene stage, followed by apoptosis. We analyzed to determine whether every event in the spermatogenesis at the Dmrt7-deficient mice progressed normally, because in several gene knockout mice with spermatogenic arrest described in the previous reports impairments of these events often appeared. Mutant mice showed normal synapsis and XY body formation, while impairment of meiotic sex chromosome inactivation (MSCI), decreased expression of backup genes, and increased expression of retrotransposons indicated incomplete meiotic recombination.

    Original languageEnglish
    Pages (from-to)1621-1626
    Number of pages6
    JournalBioscience, Biotechnology and Biochemistry
    Issue number9
    Publication statusPublished - 2012


    • Dmrt
    • Male infertility
    • Pachytene
    • Spermatogenesis
    • Spermatogenic arrest

    ASJC Scopus subject areas

    • Biotechnology
    • Analytical Chemistry
    • Biochemistry
    • Applied Microbiology and Biotechnology
    • Molecular Biology
    • Organic Chemistry


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