TY - JOUR
T1 - Improvement and recent applications of the Tohoku microbeam system
AU - Matsuyama, S.
AU - Ishii, K.
AU - Watanabe, K.
AU - Terakawa, A.
AU - Kikuchi, Y.
AU - Fujiwara, M.
AU - Sugai, H.
AU - Karahashi, M.
AU - Nozawa, Y.
AU - Yamauchi, S.
AU - Fujisawa, M.
AU - Ishiya, M.
AU - Nagaya, T.
AU - Ortega, R.
AU - Carmona, A.
AU - Roudeau, S.
N1 - Funding Information:
This study was partly supported by a Grant-in-Aid for Scientific Research, (B) No. 23360419, Ministry of Education, Culture, Sports, Science and Technology (MEXT) and a Grant-in-Aid for Challenging Exploratory Research Grant No. 23656583, Japan Society for the Promotion of Science (JSPS). This study was also supported Japan-France Integrated Action Program (SAKURA). The authors would like to thank Prof. G.W. Grime University of Surrey, for his valuable suggestions and advice in introducing WinTRAX.
PY - 2014
Y1 - 2014
N2 - The microbeam system at Tohoku University has been applied to various fields since its installation and is mainly used for biological applications. The primary purpose of this work was to develop a 3D μ-CT, in which a microbeam is used as a monoenergetic point X-ray source. The second one was to develop a microbeam analysis system for biological samples. A beam spot of 0.4 × 0.4 μm2 at a beam current of several tens of pA has been produced. However, in our set-up, μ-PIXE/RBS analyses demand beam currents of ca. 100 pA, which restricts the spatial resolution to around 1 × 1 μm2. In order to get higher spatial resolution down to several hundred nm and higher beam current with a several μm resolution, a triplet lens system was designed and newly installed. This upgrade was carried out simultaneously with the recovery from the damage caused by the great east Japan earthquake. The triplet lens system has larger demagnification and was designed by adding a quadrupole lens to the existing doublet system. Although a beam spot size of 2 × 1 μm2 is currently obtained, it has not achieved the performance obtained by the previous doublet system. The doublet system has been recovered to its previous performance and is routinely applied to simultaneous μ-PIXE/RBS analysis in various fields. Recent applications of 3D-PIXE-μ-CT of toxic elements in single cells with the new microbeam system are presented.
AB - The microbeam system at Tohoku University has been applied to various fields since its installation and is mainly used for biological applications. The primary purpose of this work was to develop a 3D μ-CT, in which a microbeam is used as a monoenergetic point X-ray source. The second one was to develop a microbeam analysis system for biological samples. A beam spot of 0.4 × 0.4 μm2 at a beam current of several tens of pA has been produced. However, in our set-up, μ-PIXE/RBS analyses demand beam currents of ca. 100 pA, which restricts the spatial resolution to around 1 × 1 μm2. In order to get higher spatial resolution down to several hundred nm and higher beam current with a several μm resolution, a triplet lens system was designed and newly installed. This upgrade was carried out simultaneously with the recovery from the damage caused by the great east Japan earthquake. The triplet lens system has larger demagnification and was designed by adding a quadrupole lens to the existing doublet system. Although a beam spot size of 2 × 1 μm2 is currently obtained, it has not achieved the performance obtained by the previous doublet system. The doublet system has been recovered to its previous performance and is routinely applied to simultaneous μ-PIXE/RBS analysis in various fields. Recent applications of 3D-PIXE-μ-CT of toxic elements in single cells with the new microbeam system are presented.
KW - μ-PIXE/RBS analyses
KW - 3D-PIXE-μ-CT
KW - Doublet
KW - Microbeam
KW - Triplet
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U2 - 10.1016/j.nimb.2013.06.056
DO - 10.1016/j.nimb.2013.06.056
M3 - Article
AN - SCOPUS:84889087363
SN - 0168-583X
VL - 318
SP - 32
EP - 36
JO - Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
JF - Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
IS - PART A
ER -