Improvement of peripheral neuropathy by testosterone in a patient with 48,XXYY syndrome

Shin Ichi Izumi, Akio Tsubahara

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


The 48,XXYY syndrome is a form of hypergonadotropic hypogonadism, characterized by tall statures, aggressive behavior, mental retardation, and stasis changes reflecting vascular insufficiency. We report a 25-year-old male with this syndrome showing a peripheral neuropathy and stasis dermatitis which were both reversed by administration of testosterone. Electrophysiologic studies, plethysmography, and thermography indicated that this treatment improved nerve conductivity and peripheral circulation. We postulate that in 48,XXYY syndrome a decrease in testosterone may result in peripheral neuropathy via nerve ischemia.

Original languageEnglish
Pages (from-to)39-44
Number of pages6
JournalTokai Journal of Experimental and Clinical Medicine
Issue number2
Publication statusPublished - 2000 Jun 1
Externally publishedYes


  • 48,XXYY syndrome
  • Electrodiagnosis
  • Ischemia
  • Peripheral neuropathy
  • Testosterone

ASJC Scopus subject areas

  • Medicine(all)


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