Improvement of trapping efficiency of microbubbles by forming time division multiple acoustic focal points

Toi Sawaguchi; Ren Koda; Naoto Hosaka; Shinya Onogi; Takashi Mochizuki; Kohji Masuda

doi:10.11239/jsmbe.52.O-327

Improvement of trapping efficiency of microbubbles by forming time division multiple acoustic focal points

Toi Sawaguchi, Ren Koda, Naoto Hosaka, Shinya Onogi, Takashi Mochizuki, Kohji Masuda

ENG - Materials Processing

Research output: Contribution to journal › Article › peer-review

Abstract

We have reported attempts to trap microcbubbles by ultrasound to increase density of microbubbles considering therapeutic efficiency. Because the form of blood vessel is complex, therapeutic efficiency will be improved by trapping in multiple areas simultaneously. However, there is a limitation of the number of transducers on body surface. In this study, we have developed a 2D-array transducer to form multiple focal points by designing the waveform. We observed microbubbles were trapped in 4 paths as shown in the figure. From the results, we confirmed the trapping efficiency was improved by comparing with the experiment of continuous emission with the same ultrasound energy above.

Original language	English
Pages (from-to)	O-327-O-328
Journal	Transactions of Japanese Society for Medical and Biological Engineering
Volume	52
DOIs	https://doi.org/10.11239/jsmbe.52.O-327
Publication status	Published - 2014 Aug 17

Keywords

Drug delivery system
Microbubble
Ultrasounds

ASJC Scopus subject areas

Biomedical Engineering

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10.11239/jsmbe.52.O-327

Cite this

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abstract = "We have reported attempts to trap microcbubbles by ultrasound to increase density of microbubbles considering therapeutic efficiency. Because the form of blood vessel is complex, therapeutic efficiency will be improved by trapping in multiple areas simultaneously. However, there is a limitation of the number of transducers on body surface. In this study, we have developed a 2D-array transducer to form multiple focal points by designing the waveform. We observed microbubbles were trapped in 4 paths as shown in the figure. From the results, we confirmed the trapping efficiency was improved by comparing with the experiment of continuous emission with the same ultrasound energy above.",

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AU - Sawaguchi, Toi

AU - Koda, Ren

AU - Hosaka, Naoto

AU - Onogi, Shinya

AU - Mochizuki, Takashi

AU - Masuda, Kohji

PY - 2014/8/17

Y1 - 2014/8/17

N2 - We have reported attempts to trap microcbubbles by ultrasound to increase density of microbubbles considering therapeutic efficiency. Because the form of blood vessel is complex, therapeutic efficiency will be improved by trapping in multiple areas simultaneously. However, there is a limitation of the number of transducers on body surface. In this study, we have developed a 2D-array transducer to form multiple focal points by designing the waveform. We observed microbubbles were trapped in 4 paths as shown in the figure. From the results, we confirmed the trapping efficiency was improved by comparing with the experiment of continuous emission with the same ultrasound energy above.

AB - We have reported attempts to trap microcbubbles by ultrasound to increase density of microbubbles considering therapeutic efficiency. Because the form of blood vessel is complex, therapeutic efficiency will be improved by trapping in multiple areas simultaneously. However, there is a limitation of the number of transducers on body surface. In this study, we have developed a 2D-array transducer to form multiple focal points by designing the waveform. We observed microbubbles were trapped in 4 paths as shown in the figure. From the results, we confirmed the trapping efficiency was improved by comparing with the experiment of continuous emission with the same ultrasound energy above.

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KW - Microbubble

KW - Ultrasounds

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Improvement of trapping efficiency of microbubbles by forming time division multiple acoustic focal points

Abstract

Keywords

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