TY - JOUR
T1 - Improvements in seasonal allergic disease with lactobacillus plantarum no. 14
AU - Nagata, Yuko
AU - Yoshida, Mutsuko
AU - Kitazawa, Haruki
AU - Araki, Eiji
AU - Gomyo, Toshiharu
PY - 2010
Y1 - 2010
N2 - We conducted two randomized, placebo-controlled, double-blind studies of Lactobacillus plantarum No. 14 (LP14) in female students with seasonal allergic diseases. We also examined the mitogenic activity and cytokine inducibility of LP14 using Peyer's patch cells and mesenteric lymph node cells of swine. For subjects who took 8.7 x 108 of LP14, a significant improvement in ocular symptom-medication score was observed. In the placebo group, the T helper type 1 (Thl)/T helper type 2 (Th2) ratio tended to decrease after a 6-week intake period, while in the LP14 group, the percentage of Thl cells significantly increased. Post-intake eosinophil counts significantly increased in comparison to those at intake cessation in the placebo group, but it appeared to be suppressed in the LP14 group. There were no changes in fecal microflora. LP14 strongly induced the gene expression of Thl-type cytokines. This study indicates the clinical effects of LP14 on seasonal allergic diseases.
AB - We conducted two randomized, placebo-controlled, double-blind studies of Lactobacillus plantarum No. 14 (LP14) in female students with seasonal allergic diseases. We also examined the mitogenic activity and cytokine inducibility of LP14 using Peyer's patch cells and mesenteric lymph node cells of swine. For subjects who took 8.7 x 108 of LP14, a significant improvement in ocular symptom-medication score was observed. In the placebo group, the T helper type 1 (Thl)/T helper type 2 (Th2) ratio tended to decrease after a 6-week intake period, while in the LP14 group, the percentage of Thl cells significantly increased. Post-intake eosinophil counts significantly increased in comparison to those at intake cessation in the placebo group, but it appeared to be suppressed in the LP14 group. There were no changes in fecal microflora. LP14 strongly induced the gene expression of Thl-type cytokines. This study indicates the clinical effects of LP14 on seasonal allergic diseases.
KW - Allergic symptom
KW - Cytokine
KW - T helper type 1 (Thl)/T helper type 2 (Th2) ratio
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UR - http://www.scopus.com/inward/citedby.url?scp=77957335014&partnerID=8YFLogxK
U2 - 10.1271/bbb.100270
DO - 10.1271/bbb.100270
M3 - Article
C2 - 20834165
AN - SCOPUS:77957335014
SN - 0916-8451
VL - 74
SP - 1869
EP - 1877
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
IS - 9
ER -