TY - JOUR
T1 - In vitro antifungal activities of lanoconazole against stock cultures and clinical isolates of Candida albicans
AU - Niwano, Yoshimi
AU - Ohmi, Tetsuto
AU - Kanai, Kazuo
AU - Hamaguchi, Hiroshi
AU - Uchida, Katsuhisa
AU - Yamaguchi, Hideyo
PY - 1995/1/1
Y1 - 1995/1/1
N2 - In vitro antifungal activities of lanoconazole (LCZ) against 9 stock cultures and 10 clinical isolates of Candida albicans were determined using three different testing media, Sabouraud's glucose broth (SGB), Sabouraud's glucose agar (SGA) and casitone agar (CA). MIC values of LCZ against both the stock cultures and clinical isolates measured on CA distributed in a range of 0.63–5 µg/ml. The values were 8–64-fold lower than those obtained in SGB and on SGA. MIC ranges and the geometric mean MIC values of LCZ against stock cultures were virtually the same as those against clinical isolates, no matter which assay techniques were used. These results suggest that there is no difference in the LCZ susceptibility between stock cultures and clinical isolates of C. albicans, although anti-Candida activity of LCZ was determined to be greater on CA than that in SGB or on SGA.
AB - In vitro antifungal activities of lanoconazole (LCZ) against 9 stock cultures and 10 clinical isolates of Candida albicans were determined using three different testing media, Sabouraud's glucose broth (SGB), Sabouraud's glucose agar (SGA) and casitone agar (CA). MIC values of LCZ against both the stock cultures and clinical isolates measured on CA distributed in a range of 0.63–5 µg/ml. The values were 8–64-fold lower than those obtained in SGB and on SGA. MIC ranges and the geometric mean MIC values of LCZ against stock cultures were virtually the same as those against clinical isolates, no matter which assay techniques were used. These results suggest that there is no difference in the LCZ susceptibility between stock cultures and clinical isolates of C. albicans, although anti-Candida activity of LCZ was determined to be greater on CA than that in SGB or on SGA.
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U2 - 10.11553/antibiotics1968b.48.140
DO - 10.11553/antibiotics1968b.48.140
M3 - Article
C2 - 7699837
AN - SCOPUS:0028870177
SN - 0368-2781
VL - 48
SP - 140
EP - 145
JO - The Journal of antibiotics. Ser. B
JF - The Journal of antibiotics. Ser. B
IS - 1
ER -
