TY - JOUR
T1 - In vitro antimicrobial activities and therapeutic effect of azthreonam (SQ 26, 776) on respiratory tract infections
AU - Onuma, Kikuo
AU - Aonuma, Seiichi
AU - Watanabe, Akira
AU - Sasaki, Masako
AU - Oizumi, Kotaro
AU - Konno, Kiyoshi
PY - 1985/1/1
Y1 - 1985/1/1
N2 - The MICs of Azthreonam(SQ 26, 776)against 121 bacterial strains from patientsș sputa were compared with those of Cefazolin, Cefmetazole, Ceftizoxime and Latamoxef on Enterobacteriaceae and with those of Piperacillin and Cefsulodin on Pseudomonas aeruginosa, and the efficacy of Azthreonam in the treatment of two patients with pneumonia which had not been cured by some other antibiotics was evaluated. The results of in vitro tests revealed that Azthreonam was as highly active against Escherichia coli, Klebsiella sp., Enterobacter sp. and Serratia sp. as Ceftizoxime and was more active than Cefazolin, Cefmetazole and Latamoxef. The antipseudomonal activity of Azthreonam was less than that of Cefsulodin but more than that of Piperacillin. Two grams of Azthreonam per day was given to the patients by intravenous drip infusion. Clinical response to the treatment was good and infiltrative shadows on the chest X-ray films disappeared in both patients. In one patient, drug fever occurred during the treatment, but body temperature became normal soon after cessation of the drug. No other side effects were observed.
AB - The MICs of Azthreonam(SQ 26, 776)against 121 bacterial strains from patientsș sputa were compared with those of Cefazolin, Cefmetazole, Ceftizoxime and Latamoxef on Enterobacteriaceae and with those of Piperacillin and Cefsulodin on Pseudomonas aeruginosa, and the efficacy of Azthreonam in the treatment of two patients with pneumonia which had not been cured by some other antibiotics was evaluated. The results of in vitro tests revealed that Azthreonam was as highly active against Escherichia coli, Klebsiella sp., Enterobacter sp. and Serratia sp. as Ceftizoxime and was more active than Cefazolin, Cefmetazole and Latamoxef. The antipseudomonal activity of Azthreonam was less than that of Cefsulodin but more than that of Piperacillin. Two grams of Azthreonam per day was given to the patients by intravenous drip infusion. Clinical response to the treatment was good and infiltrative shadows on the chest X-ray films disappeared in both patients. In one patient, drug fever occurred during the treatment, but body temperature became normal soon after cessation of the drug. No other side effects were observed.
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U2 - 10.11250/chemotherapy1953.33.Supplement1_285
DO - 10.11250/chemotherapy1953.33.Supplement1_285
M3 - Article
AN - SCOPUS:84998336336
SN - 0009-3165
VL - 33
SP - 285
EP - 288
JO - CHEMOTHERAPY
JF - CHEMOTHERAPY
ER -
