In vitro antimicrobial activities and therapeutic effects on respiratory tract infections of cefoperazone (T-1551)

From the results of in vitro tests a new semi-synthetic cephalosporin derivative, cefoperazone (CPZ, T-1551), was shown to be especially active against patient strains of gram-negative species, such as Pseudomonas aeruginosa, Klebsiella pneumoniae, E. coli and Enterobacter sp. Twenty two patients of respiratory tract infections were treated by intravenous drip infusion of one to two grams of CPZ twice a day and in most of them a positive response was obtained. No undesirable symptom was observed in them, except for drug fever in a patient and diarrhea in the other. A slight degree elevation of serum transaminases and alkaline phosphatase was seen in a few cases during the course of the treatment with the drug but the deteriorations in laboratory findings were transient and the values returned to normal levels after with drawal of the agent.