In vivo synergy between green tea extract and levofloxacin against enterohemorrhagic Escherichia coli O157 infection

Emiko Isogai; Hiroshi Isogai; Kimiharu Hirose; Shunji Hayashi; Keiji Oguma

doi:10.1007/s0028403357

In vivo synergy between green tea extract and levofloxacin against enterohemorrhagic Escherichia coli O157 infection

Emiko Isogai, Hiroshi Isogai, Kimiharu Hirose, Shunji Hayashi, Keiji Oguma

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Abstract

We studied the synergistic effects of Japanese green tea extract (JGTE) and levofloxacin (LVFX) against enterohemorrhagic Escherichia coli (EHEC) infection in a gnotobiotic mouse model. Mice fed on JGTE conferred a significant degree of protection against an oral challenge with EHEC. Complete elimination of the bacteria from the mice, was however, difficult. The combination of JGTE and LVFX increased the survival rate and reduced damage to target organs. Thus, dietary supplementation with JGTE improved the therapeutic effects of antibiotic treatment.

Original language	English
Pages (from-to)	248-251
Number of pages	4
Journal	Current Microbiology
Volume	42
Issue number	4
DOIs	https://doi.org/10.1007/s0028403357
Publication status	Published - 2001 Jan 1

ASJC Scopus subject areas

Microbiology
Applied Microbiology and Biotechnology

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abstract = "We studied the synergistic effects of Japanese green tea extract (JGTE) and levofloxacin (LVFX) against enterohemorrhagic Escherichia coli (EHEC) infection in a gnotobiotic mouse model. Mice fed on JGTE conferred a significant degree of protection against an oral challenge with EHEC. Complete elimination of the bacteria from the mice, was however, difficult. The combination of JGTE and LVFX increased the survival rate and reduced damage to target organs. Thus, dietary supplementation with JGTE improved the therapeutic effects of antibiotic treatment.",

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AU - Hayashi, Shunji

AU - Oguma, Keiji

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AB - We studied the synergistic effects of Japanese green tea extract (JGTE) and levofloxacin (LVFX) against enterohemorrhagic Escherichia coli (EHEC) infection in a gnotobiotic mouse model. Mice fed on JGTE conferred a significant degree of protection against an oral challenge with EHEC. Complete elimination of the bacteria from the mice, was however, difficult. The combination of JGTE and LVFX increased the survival rate and reduced damage to target organs. Thus, dietary supplementation with JGTE improved the therapeutic effects of antibiotic treatment.

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In vivo synergy between green tea extract and levofloxacin against enterohemorrhagic Escherichia coli O157 infection

Abstract

ASJC Scopus subject areas

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