TY - JOUR
T1 - Increase of complement fragment C5a in cerebrospinal fluid during exacerbation of neuromyelitis optica
AU - Kuroda, Hiroshi
AU - Fujihara, Kazuo
AU - Takano, Rina
AU - Takai, Yoshiki
AU - Takahashi, Toshiyuki
AU - Misu, Tatsuro
AU - Nakashima, Ichiro
AU - Sato, Shigeru
AU - Itoyama, Yasuto
AU - Aoki, Masashi
N1 - Funding Information:
This study is supported by the grants-in-aid for scientific research ( 19209032 , 20390241 , 21790828 , and 22229008 ) of the Ministry of Education, Culture, Sports, Science and Technology of Japan , and by the Health and Labour Sciences Research Grant on Intractable Diseases (Neuroimmunological Diseases) from the Ministry of Health, Labour and Welfare of Japan .
PY - 2013/1/15
Y1 - 2013/1/15
N2 - Complement is thought to play a pivotal role in neuromyelitis optica (NMO) pathogenesis. Anaphylatoxins (C3a, C4a, and C5a), produced in complement activation, have proinflammatory potential, and thereby may play an important role. We measured concentrations of anaphylatoxins in CSF and sera, obtained from patients with NMO (n = 15), multiple sclerosis (MS) (n = 15), and other neurological disease (OND) (n = 12), and evaluated their clinical implications. The CSF-C5a levels were elevated significantly in NMO patients, especially in patients with multiple enhanced lesions on MRI. The CSF-C5a levels correlated with the severity of exacerbation. Our results may provide a rationale for anti-complement therapies of NMO.
AB - Complement is thought to play a pivotal role in neuromyelitis optica (NMO) pathogenesis. Anaphylatoxins (C3a, C4a, and C5a), produced in complement activation, have proinflammatory potential, and thereby may play an important role. We measured concentrations of anaphylatoxins in CSF and sera, obtained from patients with NMO (n = 15), multiple sclerosis (MS) (n = 15), and other neurological disease (OND) (n = 12), and evaluated their clinical implications. The CSF-C5a levels were elevated significantly in NMO patients, especially in patients with multiple enhanced lesions on MRI. The CSF-C5a levels correlated with the severity of exacerbation. Our results may provide a rationale for anti-complement therapies of NMO.
KW - Anaphylatoxins
KW - C5a
KW - Cerebrospinal fluid
KW - Complement
KW - Neuromyelitis optica
KW - Relapse
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U2 - 10.1016/j.jneuroim.2012.09.002
DO - 10.1016/j.jneuroim.2012.09.002
M3 - Article
C2 - 23017732
AN - SCOPUS:84871683149
SN - 0165-5728
VL - 254
SP - 178
EP - 182
JO - Advances in Neuroimmunology
JF - Advances in Neuroimmunology
IS - 1-2
ER -