Increased affinity of endothelial cells to NiTi using ultraviolet irradiation: An in vitro study

Satoshi Tateshima, Naoki Kaneko, Masahiro Yamada, Gary Duckwiler, Fernando Vinuela, Takahiro Ogawa

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Nickel–titanium alloy (NiTi) is one of the most popular materials used endovascularly because of its shape memory and superelasticity. The NiTi device needs to be covered by endothelial cells after being placed in the blood vessel to reduce ischemic complications. The objective of this study was to examine the impact of ultraviolet (UV) irradiation on the biocompatibility of NiTi surfaces with endothelial cells. NiTi sheets were treated with UV irradiation for 48 h and human aorta derived endothelial cells were used in this study. UV irradiation converted the NiTi surface to hydrophilic state and increased albumin adsorption. The number of endothelial cell migration, attachment, proliferation as well as their metabolic activity were significantly increased on UV treated NiTi. This study provides the first evidence of the photoactivation of NiTi surfaces by UV irradiation and demonstrates improved biocompatibility of UV-treated NiTi surfaces with vascular endothelial cells. These results suggest that UV irradiation may promote endothelialization of NiTi devices in blood vessels.

Original languageEnglish
Pages (from-to)1034-1038
Number of pages5
JournalJournal of Biomedical Materials Research - Part A
Issue number4
Publication statusPublished - 2018 Apr


  • biocompatibility
  • endovascular device
  • nitinol
  • ultraviolet irradiation
  • vascular endothelial cell


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