TY - JOUR
T1 - Increased arterial carboxyhemoglobin concentrations in chronic obstructive pulmonary disease
AU - Yasuda, Hiroyasu
AU - Yamaya, Mutsuo
AU - Nakayama, Katsutoshi
AU - Ebihara, Satoru
AU - Sasaki, Takahiko
AU - Okinaga, Shoji
AU - Inoue, Daisuke
AU - Asada, Masanori
AU - Nemoto, Miyako
AU - Sasaki, Hidetada
PY - 2005/6/1
Y1 - 2005/6/1
N2 - Rationale: Exhaled carbon monoxide (CO) and arterial blood carboxyhemoglobin concentrations (Hb-CO) Increase In Inflammatory pulmonary diseases. Objectives: To study whether arterial Hb-CO Is useful to monitor disease activity In patients with chronic obstructive pulmonary disease (COPD) who had stopped smoking. Methods: We measured arterial Hb-CO, arterlovenous Hb-CO differences, and FEV, In 58 patients with COPD and 61 ex-smoking control subjects. Results: Arterial Hb-CO concentrations In patients at stable conditions were higher than those In control subjects (p < 0.0001). Furthermore, the Hb-CO concentrations In patients at the exacerbations (p < 0.0001) were higher than those at the stable conditions. Arterial Hb-CO concentrations In patients at stage III were higher than those In patients at stage II, and the Hb-CO concentrations In patients at stage IV were higher than those in patients at stage III at the stable conditions and exacerbations. Arterial Hb-CO correlated with exhaled CO In patients with COPD at stage II and stage III at the exacerbations. Arterial Hb-CO inversely correlated with the arterial blood partial oxygen pressure and FEV1. Arterlovenous Hb-CO differences in patients at the exacerbations did not differ from those In patients at stable conditions and from those In control subjects. Moreover, arterial Hb-CO correlated with serum C-reactive protein values and serum lipld peroxide concentrations. Conclusions: These findings suggest that increased arterial Hb-CO may relate to severity In patients with COPD because of lung and systemic inflammation and production of reactive oxygen species.
AB - Rationale: Exhaled carbon monoxide (CO) and arterial blood carboxyhemoglobin concentrations (Hb-CO) Increase In Inflammatory pulmonary diseases. Objectives: To study whether arterial Hb-CO Is useful to monitor disease activity In patients with chronic obstructive pulmonary disease (COPD) who had stopped smoking. Methods: We measured arterial Hb-CO, arterlovenous Hb-CO differences, and FEV, In 58 patients with COPD and 61 ex-smoking control subjects. Results: Arterial Hb-CO concentrations In patients at stable conditions were higher than those In control subjects (p < 0.0001). Furthermore, the Hb-CO concentrations In patients at the exacerbations (p < 0.0001) were higher than those at the stable conditions. Arterial Hb-CO concentrations In patients at stage III were higher than those In patients at stage II, and the Hb-CO concentrations In patients at stage IV were higher than those in patients at stage III at the stable conditions and exacerbations. Arterial Hb-CO correlated with exhaled CO In patients with COPD at stage II and stage III at the exacerbations. Arterial Hb-CO inversely correlated with the arterial blood partial oxygen pressure and FEV1. Arterlovenous Hb-CO differences in patients at the exacerbations did not differ from those In patients at stable conditions and from those In control subjects. Moreover, arterial Hb-CO correlated with serum C-reactive protein values and serum lipld peroxide concentrations. Conclusions: These findings suggest that increased arterial Hb-CO may relate to severity In patients with COPD because of lung and systemic inflammation and production of reactive oxygen species.
KW - Carbon monoxide
KW - Carboxyhemoglobin
KW - Chronic obstructive pulmonary disease
KW - Heme oxygenase
KW - Systemic inflammation
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U2 - 10.1164/rccm.200407-914OC
DO - 10.1164/rccm.200407-914OC
M3 - Article
C2 - 15764730
AN - SCOPUS:21144450323
SN - 1073-449X
VL - 171
SP - 1246
EP - 1251
JO - American Journal of Respiratory and Critical Care Medicine
JF - American Journal of Respiratory and Critical Care Medicine
IS - 11
ER -